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Fig. 8 | BMC Cancer

Fig. 8

From: The NF-κB p65 and p50 homodimer cooperate with IRF8 to activate iNOS transcription

Fig. 8

Model of IFNγ and NF-κB action in induction of iNOS expression in myeloid cells. IFNγ and NF-κB induces iNOS expression in tumor cells and myeloid cells. Both IFNγ-activated pSTAT1 and NF-κB are essential for the induction of iNOS. However, IFNγ-activated pSTAT1 does not directly bind to the nos2 gene promoter. Instead, it activates IRF8 to regulate iNOS transcription. On the other hand, NF-κB directly binds to the nos2 gene promoter to activate iNOS transcription and it is the p65/p65 and p50/p50 NF-κB homodimers, not the canonical p65/p50 heterodimer, that bind to the nos2 promoter region to activate iNOS transcription in myeloid cells

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