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Fig. 2 | BMC Cancer

Fig. 2

From: Suppression of Homologous Recombination by insulin-like growth factor-1 inhibition sensitizes cancer cells to PARP inhibitors

Fig. 2

Reduced RAD51 foci formation in cancer cells with low/absent BRCA1 expression. Cells were treated with 1ug/ml cisplatin for one hour, allowed to recover for six hours and then fixed for immunofluorescence. Immunofluorescence staining images of RAD51 foci in ovarian (a, c) and breast (e) cancer cells with respect to the BRCA1 protein expression are shown at 100X magnification. Quantitative representation of the percentage of cells with positive RAD51 foci is shown in fig (b, d, f). Cells with >5 foci/nucleus were considered positive. Results represent the average of three independent experiments. *p < 0.05

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BMC Cancer

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