Skip to main content

Advertisement

Fig. 6 | BMC Cancer

Fig. 6

From: Association of activated Gαq to the tumor suppressor Fhit is enhanced by phospholipase Cβ

Fig. 6

The binding regions of Fhit and PLCβ on activated Gαq surface. Molecular surface of activated Gαq was modeled based on the crystal structures of activated Gαq and PLCβ3 (PDB: 4GNK). a The location of the Fhit-interacting α2-β4 regions (Gly208-Asp243, purple) relative to the other domains (white) on Gαq is illustrated. b The contact interface of activated Gαq with PLCβ3 is highlighted in yellow. c Overlapped binding regions of PLCβ and Fhit on activated Gαq is shown in green. d PLCβ increases the interaction between Gαq and Fhit. Gαq does not enhance the interaction between PLCβ and Fhit. And Fhit is unable to strengthen the association of Gαq and PLCβ

Back to article page