Fig. 2

Recommended treatment and time of biopsies. Patients with previously untreated, advanced stage cervical cancer (stage IB2-IV) will be enrolled in BIO-RAIDs study and undergo standard treatment. The recommendations for standards of treatment by stage and the timing of biopsies are shown. B1: biopsy before treatment; B2: biopsy during or at the end of treatment in case of poor response/progression; B3: biopsy in case of recurrence