Table 3 Univariate and multivariate analysis of prognostic factors in patients with hilar cholangiocarcinoma
From: Prognostic significance of macrophage invasion in hilar cholangiocarcinoma
Variable | Category | Odds ratio | p | Confidence interval |
|---|---|---|---|---|
Univariate analysis | ||||
Age | ≤60/>60 | 1.588 | 0.239 | 0.735–3.430 |
Gender | male/female | 1.287 | 0.517 | 0.600–2.761 |
perivascular lymphangiosis | negative/positive | 0.734 | 0.430 | 0.340–1.583 |
R-Classification | negative/positive | 2.325 | 0.039 | 1.042–5.189 |
Histologic differentiation | well or moderate/poor | 2.141 | 0.103 | 0.857–5.344 |
Vascular invasion | negative/positive | 1.285 | 0.569 | 0.542–3.045 |
pT | pT2/pT3 | 1.242 | 0.597 | 0.557–2.768 |
pN | negative/positive | 0.535 | 0.124 | 0.242–1.186 |
Perineural sheet infiltration | negative/positive | 0.289 | 0.224 | 0.039–2.137 |
Lymphangiosis carcinomatosa | negative/positive | 0.835 | 0.651 | 0.381–1.827 |
CD68 + TAMs | high/low | 0.977 | 0.951 | 0.457–2.088 |
CD68 + TAMs in TIF | high/low | 0.322 | 0.013 | 0.132–0.784 |
Overall Tumor Recurrence | negative/positive | 0.112 | 0.001 | 0.033–0.37 |
Distant Metastasis | negative/positive | 0.528 | 0.111 | 0.240–1.159 |
Local Tumor Recurrence | negative/positive | 0.183 | 0.001 | 0.076–0.441 |
Multivariate analysis | ||||
R Classification | negative/positive | 0.830 | 0.710 | 0.312–2.212 |
Overall Tumor Recurrence | negative/positive | 0.172 | 0.024 | 0.037–0.794 |
Local Tumor Recurrence | negative/positive | 0.544 | 0.432 | 0.119–2.486 |
CD68-positive TAMs in TIF | high/low | 0.856 | 0.780 | 0.287–2.553 |
Multivariate analysis (Recurrence free survival) | ||||
R0 & R1/2 surgery/n = 47 | ||||
R Classification | negative/positive | 1.935 | 0.149 | 0.789–4.743 |
CD68-positive TAMs in TIF | high/low | 0.324 | 0.014 | 0.132–0.796 |
R0 & R1/2 surgery/n = 47 | ||||
only R0 surgery/n = 37 | ||||
Histologic Differentiation | well or moderate/poor | 2.549 | 0.109 | 0.811–8.012 |
CD68-positive TAMs in TIF | high/low | 0.286 | 0.024 | 0.097–0.846 |
only R0 surgery/n = 37 | ||||