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Table 3 Univariate and multivariate analysis of prognostic factors in patients with hilar cholangiocarcinoma

From: Prognostic significance of macrophage invasion in hilar cholangiocarcinoma

Variable Category Odds ratio p Confidence interval
Univariate analysis
Age ≤60/>60 1.588 0.239 0.735–3.430
Gender male/female 1.287 0.517 0.600–2.761
perivascular lymphangiosis negative/positive 0.734 0.430 0.340–1.583
R-Classification negative/positive 2.325 0.039 1.042–5.189
Histologic differentiation well or moderate/poor 2.141 0.103 0.857–5.344
Vascular invasion negative/positive 1.285 0.569 0.542–3.045
pT pT2/pT3 1.242 0.597 0.557–2.768
pN negative/positive 0.535 0.124 0.242–1.186
Perineural sheet infiltration negative/positive 0.289 0.224 0.039–2.137
Lymphangiosis carcinomatosa negative/positive 0.835 0.651 0.381–1.827
CD68 + TAMs high/low 0.977 0.951 0.457–2.088
CD68 + TAMs in TIF high/low 0.322 0.013 0.132–0.784
Overall Tumor Recurrence negative/positive 0.112 0.001 0.033–0.37
Distant Metastasis negative/positive 0.528 0.111 0.240–1.159
Local Tumor Recurrence negative/positive 0.183 0.001 0.076–0.441
Multivariate analysis
R Classification negative/positive 0.830 0.710 0.312–2.212
Overall Tumor Recurrence negative/positive 0.172 0.024 0.037–0.794
Local Tumor Recurrence negative/positive 0.544 0.432 0.119–2.486
CD68-positive TAMs in TIF high/low 0.856 0.780 0.287–2.553
Multivariate analysis (Recurrence free survival)
R0 & R1/2 surgery/n = 47
R Classification negative/positive 1.935 0.149 0.789–4.743
CD68-positive TAMs in TIF high/low 0.324 0.014 0.132–0.796
R0 & R1/2 surgery/n = 47
only R0 surgery/n = 37
Histologic Differentiation well or moderate/poor 2.549 0.109 0.811–8.012
CD68-positive TAMs in TIF high/low 0.286 0.024 0.097–0.846
only R0 surgery/n = 37