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Fig. 1 | BMC Cancer

Fig. 1

From: Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compounds

Fig. 1

Generation of SINE compound-resistant HT1080 cells. a HT1080 parental cells grown in 0, 3.7, 12.3, 111, 333, and 1000 nM KPT-185 in an 8 day clonal assay (stained with gentian violet) for the selection of the KPT concentration to initiate generation of the resistant cell line. b IC50 values for parental and resistant cells treated with KPT-185, KPT-330, and LMB, determined in an MTT assay. c HT1080 parental and resistant cells grown in 1 μM KPT-185 in the 8 day clonal growth assay (stained with gentian violet). d FACS cell-cycle analysis of HT1080 parental and resistant cells treated with 0 or 600 nM KPT-185 for 1–3 days

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