TY - JOUR AU - Chook, Y. M. AU - Suel, K. E. PY - 2011 DA - 2011// TI - Nuclear import by karyopherin-betas: recognition and inhibition JO - Biochim Biophys Acta VL - 1813 UR - https://doi.org/10.1016/j.bbamcr.2010.10.014 DO - 10.1016/j.bbamcr.2010.10.014 ID - Chook2011 ER - TY - JOUR AU - Shen, A. AU - Wang, Y. AU - Zhao, Y. AU - Zou, L. AU - Sun, L. AU - Cheng, C. PY - 2009 DA - 2009// TI - Expression of CRM1 in human gliomas and its significance in p27 expression and clinical prognosis JO - Neurosurgery VL - 65 UR - https://doi.org/10.1227/01.NEU.0000348550.47441.4B DO - 10.1227/01.NEU.0000348550.47441.4B ID - Shen2009 ER - TY - JOUR AU - Noske, A. AU - Weichert, W. AU - Niesporek, S. AU - Roske, A. AU - Buckendahl, A. C. AU - Koch, I. PY - 2008 DA - 2008// TI - Expression of the nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 is a prognostic factor in human ovarian cancer JO - Cancer VL - 112 UR - https://doi.org/10.1002/cncr.23354 DO - 10.1002/cncr.23354 ID - Noske2008 ER - TY - JOUR AU - Yao, Y. AU - Dong, Y. AU - Lin, F. AU - Zhao, H. AU - Shen, Z. AU - Chen, P. PY - 2009 DA - 2009// TI - The expression of CRM1 is associated with prognosis in human osteosarcoma JO - Oncol Rep VL - 21 ID - Yao2009 ER - TY - JOUR AU - Huang, W. Y. AU - Yue, L. AU - Qiu, W. S. AU - Wang, L. W. AU - Zhou, X. H. AU - Sun, Y. J. PY - 2009 DA - 2009// TI - Prognostic value of CRM1 in pancreas cancer JO - Clin Invest Med VL - 32 ID - Huang2009 ER - TY - JOUR AU - Watt, P. J. AU - Maske, C. P. AU - Hendricks, D. T. AU - Parker, M. I. AU - Denny, L. AU - Govender, D. PY - 2009 DA - 2009// TI - The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation JO - Int J Cancer VL - 124 UR - https://doi.org/10.1002/ijc.24146 DO - 10.1002/ijc.24146 ID - Watt2009 ER - TY - JOUR AU - Inoue, H. AU - Kauffman, M. AU - Shacham, S. AU - Landesman, Y. AU - Yang, J. AU - Evans, C. P. PY - 2013 DA - 2013// TI - CRM1 blockade by selective inhibitors of nuclear export attenuates kidney cancer growth JO - J Urol VL - 189 UR - https://doi.org/10.1016/j.juro.2012.10.018 DO - 10.1016/j.juro.2012.10.018 ID - Inoue2013 ER - TY - JOUR AU - Pathria, G. AU - Wagner, C. AU - Wagner, S. N. PY - 2012 DA - 2012// TI - Inhibition of CRM1-mediated nucleocytoplasmic transport: triggering human melanoma cell apoptosis by perturbing multiple cellular pathways JO - J Invest Dermatol VL - 132 UR - https://doi.org/10.1038/jid.2012.233 DO - 10.1038/jid.2012.233 ID - Pathria2012 ER - TY - JOUR AU - Zhang, K. AU - Wang, M. AU - Tamayo, A. T. AU - Shacham, S. AU - Kauffman, M. AU - Lee, J. PY - 2013 DA - 2013// TI - Novel selective inhibitors of nuclear export CRM1 antagonists for therapy in mantle cell lymphoma JO - Exp Hematol VL - 41 UR - https://doi.org/10.1016/j.exphem.2012.09.002 DO - 10.1016/j.exphem.2012.09.002 ID - Zhang2013 ER - TY - JOUR AU - Kojima, K. AU - Kornblau, S. M. AU - Ruvolo, V. AU - Dilip, A. AU - Duvvuri, S. AU - Davis, R. E. PY - 2013 DA - 2013// TI - Prognostic impact and targeting of CRM1 in acute myeloid leukemia JO - Blood VL - 121 UR - https://doi.org/10.1182/blood-2012-08-447581 DO - 10.1182/blood-2012-08-447581 ID - Kojima2013 ER - TY - JOUR AU - Schmidt, J. AU - Braggio, E. AU - Kortuem, K. M. AU - Egan, J. B. AU - Zhu, Y. X. AU - Xin, C. S. PY - 2013 DA - 2013// TI - Genome-wide studies in multiple myeloma identify XPO1/CRM1 as a critical target validated using the selective nuclear export inhibitor KPT-276 JO - Leukemia ID - Schmidt2013 ER - TY - JOUR AU - Tai, Y. T. AU - Landesman, Y. AU - Acharya, C. AU - Calle, Y. AU - Zhong, M. Y. AU - Cea, M. PY - 2014 DA - 2014// TI - CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications JO - Leukemia VL - 28 UR - https://doi.org/10.1038/leu.2013.115 DO - 10.1038/leu.2013.115 ID - Tai2014 ER - TY - JOUR AU - Walker, C. J. AU - Oaks, J. J. AU - Santhanam, R. AU - Neviani, P. AU - Harb, J. G. AU - Ferenchak, G. PY - 2013 DA - 2013// TI - Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph + leukemias JO - Blood ID - Walker2013 ER - TY - JOUR AU - Kanai, M. AU - Hanashiro, K. AU - Kim, S. H. AU - Hanai, S. AU - Boulares, A. H. AU - Miwa, M. PY - 2007 DA - 2007// TI - Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation JO - Nat Cell Biol VL - 9 UR - https://doi.org/10.1038/ncb1638 DO - 10.1038/ncb1638 ID - Kanai2007 ER - TY - JOUR AU - Shao, C. AU - Lu, C. AU - Chen, L. AU - Koty, P. P. AU - Cobos, E. AU - Gao, W. PY - 2011 DA - 2011// TI - p53-Dependent anticancer effects of leptomycin B on lung adenocarcinoma JO - Cancer Chemother Pharmacol VL - 67 UR - https://doi.org/10.1007/s00280-010-1434-6 DO - 10.1007/s00280-010-1434-6 ID - Shao2011 ER - TY - JOUR AU - Azmi, A. S. AU - Aboukameel, A. AU - Bao, B. AU - Sarkar, F. H. AU - Philip, P. A. AU - Kauffman, M. PY - 2013 DA - 2013// TI - Selective inhibitors of nuclear export block pancreatic cancer cell proliferation and reduce tumor growth in mice JO - Gastroenterology VL - 144 UR - https://doi.org/10.1053/j.gastro.2012.10.036 DO - 10.1053/j.gastro.2012.10.036 ID - Azmi2013 ER - TY - JOUR AU - Turner, J. G. AU - Dawson, J. AU - Sullivan, D. M. PY - 2012 DA - 2012// TI - Nuclear export of proteins and drug resistance in cancer JO - Biochem Pharmacol VL - 83 UR - https://doi.org/10.1016/j.bcp.2011.12.016 DO - 10.1016/j.bcp.2011.12.016 ID - Turner2012 ER - TY - JOUR AU - Connor, M. K. AU - Kotchetkov, R. AU - Cariou, S. AU - Resch, A. AU - Lupetti, R. AU - Beniston, R. G. PY - 2003 DA - 2003// TI - CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis JO - Mol Biol Cell VL - 14 UR - https://doi.org/10.1091/mbc.E02-06-0319 DO - 10.1091/mbc.E02-06-0319 ID - Connor2003 ER - TY - JOUR AU - Vogt, P. K. AU - Jiang, H. AU - Aoki, M. PY - 2005 DA - 2005// TI - Triple layer control: phosphorylation, acetylation and ubiquitination of FOXO proteins JO - Cell Cycle VL - 4 UR - https://doi.org/10.4161/cc.4.7.1796 DO - 10.4161/cc.4.7.1796 ID - Vogt2005 ER - TY - JOUR AU - Huang, T. T. AU - Kudo, N. AU - Yoshida, M. AU - Miyamoto, S. PY - 2000 DA - 2000// TI - A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexes JO - Proc Natl Acad Sci U S A VL - 97 UR - https://doi.org/10.1073/pnas.97.3.1014 DO - 10.1073/pnas.97.3.1014 ID - Huang2000 ER - TY - JOUR AU - Roth, D. M. AU - Harper, I. AU - Pouton, C. W. AU - Jans, D. A. PY - 2009 DA - 2009// TI - Modulation of nucleocytoplasmic trafficking by retention in cytoplasm or nucleus JO - J Cell Biochem VL - 107 UR - https://doi.org/10.1002/jcb.22218 DO - 10.1002/jcb.22218 ID - Roth2009 ER - TY - JOUR AU - Brodie, K. M. AU - Henderson, B. R. PY - 2012 DA - 2012// TI - Characterization of BRCA1 protein targeting, dynamics, and function at the centrosome: a role for the nuclear export signal, CRM1, and Aurora A kinase JO - J Biol Chem VL - 287 UR - https://doi.org/10.1074/jbc.M111.327296 DO - 10.1074/jbc.M111.327296 ID - Brodie2012 ER - TY - JOUR AU - Thakar, K. AU - Karaca, S. AU - Port, S. A. AU - Urlaub, H. AU - Kehlenbach, R. H. PY - 2013 DA - 2013// TI - Identification of CRM1-dependent nuclear export cargos using quantitative mass spectrometry JO - Mol Cell Proteomics VL - 12 UR - https://doi.org/10.1074/mcp.M112.024877 DO - 10.1074/mcp.M112.024877 ID - Thakar2013 ER - TY - JOUR AU - Hutten, S. AU - Kehlenbach, R. H. PY - 2007 DA - 2007// TI - CRM1-mediated nuclear export: to the pore and beyond JO - Trends Cell Biol VL - 17 UR - https://doi.org/10.1016/j.tcb.2007.02.003 DO - 10.1016/j.tcb.2007.02.003 ID - Hutten2007 ER - TY - JOUR AU - Hamamoto, T. AU - Gunji, S. AU - Tsuji, H. AU - Beppu, T. PY - 1983 DA - 1983// TI - Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization JO - J Antibiot (Tokyo) VL - 36 UR - https://doi.org/10.7164/antibiotics.36.639 DO - 10.7164/antibiotics.36.639 ID - Hamamoto1983 ER - TY - JOUR AU - Nishi, K. AU - Yoshida, M. AU - Fujiwara, D. AU - Nishikawa, M. AU - Horinouchi, S. AU - Beppu, T. PY - 1994 DA - 1994// TI - Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression JO - J Biol Chem VL - 269 ID - Nishi1994 ER - TY - JOUR AU - Kudo, N. AU - Matsumori, N. AU - Taoka, H. AU - Fujiwara, D. AU - Schreiner, E. P. AU - Wolff, B. PY - 1999 DA - 1999// TI - Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region JO - Proc Natl Acad Sci U S A VL - 96 UR - https://doi.org/10.1073/pnas.96.16.9112 DO - 10.1073/pnas.96.16.9112 ID - Kudo1999 ER - TY - JOUR AU - Newlands, E. S. AU - Rustin, G. J. AU - Brampton, M. H. PY - 1996 DA - 1996// TI - Phase I trial of elactocin JO - Br J Cancer VL - 74 UR - https://doi.org/10.1038/bjc.1996.415 DO - 10.1038/bjc.1996.415 ID - Newlands1996 ER - TY - JOUR AU - Sakakibara, K. AU - Saito, N. AU - Sato, T. AU - Suzuki, A. AU - Hasegawa, Y. AU - Friedman, J. M. PY - 2011 DA - 2011// TI - CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity JO - Blood VL - 118 UR - https://doi.org/10.1182/blood-2011-01-333138 DO - 10.1182/blood-2011-01-333138 ID - Sakakibara2011 ER - TY - JOUR AU - Neck, T. AU - Pannecouque, C. AU - Vanstreels, E. AU - Stevens, M. AU - Dehaen, W. AU - Daelemans, D. PY - 2008 DA - 2008// TI - Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action JO - Bioorg Med Chem VL - 16 UR - https://doi.org/10.1016/j.bmc.2008.09.051 DO - 10.1016/j.bmc.2008.09.051 ID - Neck2008 ER - TY - JOUR AU - Lapalombella, R. AU - Sun, Q. AU - Williams, K. AU - Tangeman, L. AU - Jha, S. AU - Zhong, Y. PY - 2012 DA - 2012// TI - Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia JO - Blood VL - 120 UR - https://doi.org/10.1182/blood-2012-05-429506 DO - 10.1182/blood-2012-05-429506 ID - Lapalombella2012 ER - TY - JOUR AU - Etchin, J. AU - Sun, Q. AU - Kentsis, A. AU - Farmer, A. AU - Zhang, Z. C. AU - Sanda, T. PY - 2013 DA - 2013// TI - Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells JO - Leukemia VL - 27 UR - https://doi.org/10.1038/leu.2012.219 DO - 10.1038/leu.2012.219 ID - Etchin2013 ER - TY - JOUR AU - Sun, Q. AU - Carrasco, Y. P. AU - Hu, Y. AU - Guo, X. AU - Mirzaei, H. AU - Macmillan, J. PY - 2013 DA - 2013// TI - Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1 JO - Proc Natl Acad Sci U S A VL - 110 UR - https://doi.org/10.1073/pnas.1217203110 DO - 10.1073/pnas.1217203110 ID - Sun2013 ER - TY - JOUR AU - Yoshimura, M. AU - Ishizawa, J. AU - Ruvolo, V. AU - Dilip, A. AU - Quintas-Cardama, A. AU - McDonnell, T. J. PY - 2014 DA - 2014// TI - Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma JO - Cancer Sci VL - 105 UR - https://doi.org/10.1111/cas.12430 DO - 10.1111/cas.12430 ID - Yoshimura2014 ER - TY - JOUR AU - Han, X. AU - Wang, J. AU - Shen, Y. AU - Zhang, N. AU - Wang, S. AU - Yao, J. PY - 2015 DA - 2015// TI - CRM1 as a new therapeutic target for non-Hodgkin lymphoma JO - Leuk Res VL - 39 UR - https://doi.org/10.1016/j.leukres.2014.10.003 DO - 10.1016/j.leukres.2014.10.003 ID - Han2015 ER - TY - JOUR AU - Etchin, J. AU - Sanda, T. AU - Mansour, M. R. AU - Kentsis, A. AU - Montero, J. AU - Le, B. T. PY - 2013 DA - 2013// TI - KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia JO - Br J Haematol VL - 161 UR - https://doi.org/10.1111/bjh.12231 DO - 10.1111/bjh.12231 ID - Etchin2013 ER - TY - JOUR AU - Ranganathan, P. AU - Yu, X. AU - Na, C. AU - Santhanam, R. AU - Shacham, S. AU - Kauffman, M. PY - 2012 DA - 2012// TI - Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia JO - Blood VL - 120 UR - https://doi.org/10.1182/blood-2012-04-423160 DO - 10.1182/blood-2012-04-423160 ID - Ranganathan2012 ER - TY - JOUR AU - Zhong, Y. AU - El-Gamal, D. AU - Dubovsky, J. A. AU - Beckwith, K. A. AU - Harrington, B. K. AU - Williams, K. E. PY - 2014 DA - 2014// TI - Selinexor suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells JO - Leukemia VL - 28 UR - https://doi.org/10.1038/leu.2014.9 DO - 10.1038/leu.2014.9 ID - Zhong2014 ER - TY - JOUR AU - Cheng, Y. AU - Holloway, M. P. AU - Nguyen, K. AU - McCauley, D. AU - Landesman, Y. AU - Kauffman, M. G. PY - 2014 DA - 2014// TI - XPO1 (CRM1) inhibition represses STAT3 activation to drive a survivin-dependent oncogenic switch in triple-negative breast cancer JO - Mol Cancer Ther VL - 13 UR - https://doi.org/10.1158/1535-7163.MCT-13-0416 DO - 10.1158/1535-7163.MCT-13-0416 ID - Cheng2014 ER - TY - JOUR AU - Wettersten, H. I. AU - Landesman, Y. AU - Friedlander, S. AU - Shacham, S. AU - Kauffman, M. AU - Weiss, R. H. PY - 2014 DA - 2014// TI - Specific inhibition of the nuclear exporter exportin-1 attenuates kidney cancer growth JO - PLoS One VL - 9 UR - https://doi.org/10.1371/journal.pone.0113867 DO - 10.1371/journal.pone.0113867 ID - Wettersten2014 ER - TY - JOUR AU - Gao, J. AU - Azmi, A. S. AU - Aboukameel, A. AU - Kauffman, M. AU - Shacham, S. AU - Abou-Samra, A. B. PY - 2014 DA - 2014// TI - Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer JO - Oncotarget VL - 5 UR - https://doi.org/10.18632/oncotarget.1813 DO - 10.18632/oncotarget.1813 ID - Gao2014 ER - TY - JOUR AU - Salas Fragomeni, R. A. AU - Chung, H. W. AU - Landesman, Y. AU - Senapedis, W. AU - Saint-Martin, J. R. AU - Tsao, H. PY - 2013 DA - 2013// TI - CRM1 and BRAF Inhibition Synergize and Induce Tumor Regression in BRAF-Mutant Melanoma JO - Mol Cancer Ther VL - 12 UR - https://doi.org/10.1158/1535-7163.MCT-12-1171 DO - 10.1158/1535-7163.MCT-12-1171 ID - Salas Fragomeni2013 ER - TY - JOUR AU - Yang, J. AU - Bill, M. A. AU - Young, G. S. AU - Perle, K. AU - Landesman, Y. AU - Shacham, S. PY - 2014 DA - 2014// TI - Novel small molecule XPO1/CRM1 inhibitors induce nuclear accumulation of TP53, phosphorylated MAPK and apoptosis in human melanoma cells JO - PLoS One VL - 9 UR - https://doi.org/10.1371/journal.pone.0102983 DO - 10.1371/journal.pone.0102983 ID - Yang2014 ER - TY - JOUR AU - Sun, H. AU - Hattori, N. AU - Chien, W. AU - Sun, Q. AU - Sudo, M. AU - E-Ling, G. L. PY - 2014 DA - 2014// TI - KPT-330 has antitumour activity against non-small cell lung cancer JO - Br J Cancer VL - 111 UR - https://doi.org/10.1038/bjc.2014.260 DO - 10.1038/bjc.2014.260 ID - Sun2014 ER - TY - JOUR AU - Wang, S. AU - Han, X. AU - Wang, J. AU - Yao, J. AU - Shi, Y. PY - 2014 DA - 2014// TI - Antitumor effects of a novel chromosome region maintenance 1 (CRM1) inhibitor on non-small cell lung cancer cells in vitro and in mouse tumor xenografts JO - PLoS One VL - 9 UR - https://doi.org/10.1371/journal.pone.0089848 DO - 10.1371/journal.pone.0089848 ID - Wang2014 ER - TY - JOUR AU - Green, A. L. AU - Ramkissoon, S. H. AU - McCauley, D. AU - Jones, K. AU - Perry, J. A. AU - Hsu, J. H. PY - 2014 DA - 2014// TI - Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma JO - Neuro Oncol VL - 17 UR - https://doi.org/10.1093/neuonc/nou303 DO - 10.1093/neuonc/nou303 ID - Green2014 ER - TY - JOUR AU - Zheng, Y. AU - Gery, S. AU - Sun, H. AU - Shacham, S. AU - Kauffman, M. AU - Koeffler, H. P. PY - 2014 DA - 2014// TI - KPT-330 inhibitor of XPO1-mediated nuclear export has anti-proliferative activity in hepatocellular carcinoma JO - Cancer Chemother Pharmacol VL - 74 UR - https://doi.org/10.1007/s00280-014-2495-8 DO - 10.1007/s00280-014-2495-8 ID - Zheng2014 ER - TY - JOUR AU - Lin, D. C. AU - Hao, J. J. AU - Nagata, Y. AU - Xu, L. AU - Shang, L. AU - Meng, X. PY - 2014 DA - 2014// TI - Genomic and molecular characterization of esophageal squamous cell carcinoma JO - Nat Genet VL - 46 UR - https://doi.org/10.1038/ng.2935 DO - 10.1038/ng.2935 ID - Lin2014 ER - TY - JOUR AU - Gravina, G. L. AU - Tortoreto, M. AU - Mancini, A. AU - Addis, A. AU - Cesare, E. AU - Lenzi, A. PY - 2014 DA - 2014// TI - XPO1/CRM1-selective inhibitors of nuclear export (SINE) reduce tumor spreading and improve overall survival in preclinical models of prostate cancer (PCa) JO - J Hematol Oncol VL - 7 UR - https://doi.org/10.1186/1756-8722-7-46 DO - 10.1186/1756-8722-7-46 ID - Gravina2014 ER - TY - JOUR AU - Mendonca, J. AU - Sharma, A. AU - Kim, H. S. AU - Hammers, H. AU - Meeker, A. AU - Marzo, A. PY - 2014 DA - 2014// TI - Selective inhibitors of nuclear export (SINE) as novel therapeutics for prostate cancer JO - Oncotarget VL - 5 UR - https://doi.org/10.18632/oncotarget.2174 DO - 10.18632/oncotarget.2174 ID - Mendonca2014 ER - TY - JOUR AU - Holohan, C. AU - Schaeybroeck, S. AU - Longley, D. B. AU - Johnston, P. G. PY - 2013 DA - 2013// TI - Cancer drug resistance: an evolving paradigm JO - Nat Rev Cancer VL - 13 UR - https://doi.org/10.1038/nrc3599 DO - 10.1038/nrc3599 ID - Holohan2013 ER - TY - JOUR AU - Rasheed, S. AU - Nelson-Rees, W. A. AU - Toth, E. M. AU - Arnstein, P. AU - Gardner, M. B. PY - 1974 DA - 1974// TI - Characterization of a newly derived human sarcoma cell line (HT-1080) JO - Cancer VL - 33 UR - https://doi.org/3.0.CO;2-Z DO - 3.0.CO;2-Z ID - Rasheed1974 ER - TY - STD TI - Phelan MC. Basic techniques in mammalian cell tissue culture. Curr Protoc Cell Biol. 2007; Chapter 1: Unit 1 doi:10.1002/0471143030.cb0101s36. ID - ref53 ER - TY - JOUR AU - Senapedis, W. T. AU - Baloglu, E. AU - Landesman, Y. PY - 2014 DA - 2014// TI - Clinical translation of nuclear export inhibitors in cancer JO - Semin Cancer Biol VL - 27 UR - https://doi.org/10.1016/j.semcancer.2014.04.005 DO - 10.1016/j.semcancer.2014.04.005 ID - Senapedis2014 ER - TY - JOUR AU - Tan, D. S. AU - Bedard, P. L. AU - Kuruvilla, J. AU - Siu, L. L. AU - Razak, A. R. PY - 2014 DA - 2014// TI - Promising SINEs for embargoing nuclear-cytoplasmic export as an anticancer strategy JO - Cancer Discov VL - 4 UR - https://doi.org/10.1158/2159-8290.CD-13-1005 DO - 10.1158/2159-8290.CD-13-1005 ID - Tan2014 ER - TY - JOUR AU - Gravina, G. AU - Senapedis, W. AU - McCauley, D. AU - Baloglu, E. AU - Shacham, S. AU - Festuccia, C. PY - 2014 DA - 2014// TI - Nucleo-cytoplasmic transport as a therapeutic target of cancer JO - J Hematol Oncol VL - 7 UR - https://doi.org/10.1186/s13045-014-0085-1 DO - 10.1186/s13045-014-0085-1 ID - Gravina2014 ER - TY - JOUR AU - Neggers, J. E. AU - Vercruysse, T. AU - Jacquemyn, M. AU - Vanstreels, E. AU - Baloglu, E. AU - Shacham, S. PY - 2015 DA - 2015// TI - Identifying drug-target selectivity of small-molecule CRM1/XPO1 inhibitors by CRISPR/Cas9 genome editing JO - Chem Biol VL - 22 UR - https://doi.org/10.1016/j.chembiol.2014.11.015 DO - 10.1016/j.chembiol.2014.11.015 ID - Neggers2015 ER - TY - JOUR AU - Mahon, F. X. AU - Deininger, M. W. AU - Schultheis, B. AU - Chabrol, J. AU - Reiffers, J. AU - Goldman, J. M. PY - 2000 DA - 2000// TI - Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance JO - Blood VL - 96 ID - Mahon2000 ER - TY - JOUR AU - Wang, N. N. AU - Zhao, L. J. AU - Wu, L. N. AU - He, M. F. AU - Qu, J. W. AU - Zhao, Y. B. PY - 2013 DA - 2013// TI - Mechanistic analysis of taxol-induced multidrug resistance in an ovarian cancer cell line JO - Asian Pac J Cancer Prev VL - 14 UR - https://doi.org/10.7314/APJCP.2013.14.9.4983 DO - 10.7314/APJCP.2013.14.9.4983 ID - Wang2013 ER - TY - JOUR AU - Juengel, E. AU - Makarevic, J. AU - Tsaur, I. AU - Bartsch, G. AU - Nelson, K. AU - Haferkamp, A. PY - 2013 DA - 2013// TI - Resistance after chronic application of the HDAC-inhibitor valproic acid is associated with elevated Akt activation in renal cell carcinoma in vivo JO - PLoS One VL - 8 UR - https://doi.org/10.1371/journal.pone.0053100 DO - 10.1371/journal.pone.0053100 ID - Juengel2013 ER - TY - JOUR AU - Stamatakos, M. AU - Palla, V. AU - Karaiskos, I. AU - Xiromeritis, K. AU - Alexiou, I. AU - Pateras, I. PY - 2010 DA - 2010// TI - Cell cyclins: triggering elements of cancer or not? JO - World J Surg Oncol VL - 8 UR - https://doi.org/10.1186/1477-7819-8-111 DO - 10.1186/1477-7819-8-111 ID - Stamatakos2010 ER - TY - JOUR AU - Shen, T. AU - Huang, S. PY - 2012 DA - 2012// TI - The role of Cdc25A in the regulation of cell proliferation and apoptosis JO - Anticancer Agents Med Chem VL - 12 UR - https://doi.org/10.2174/187152012800617678 DO - 10.2174/187152012800617678 ID - Shen2012 ER - TY - JOUR AU - Petrakis, T. G. AU - Vougas, K. AU - Gorgoulis, V. G. PY - 2012 DA - 2012// TI - Cdc6: a multi-functional molecular switch with critical role in carcinogenesis JO - Transcription VL - 3 UR - https://doi.org/10.4161/trns.20301 DO - 10.4161/trns.20301 ID - Petrakis2012 ER - TY - JOUR AU - Findlay, V. J. AU - Wang, C. AU - Watson, D. K. AU - Camp, E. R. PY - 2014 DA - 2014// TI - Epithelial-to-mesenchymal transition and the cancer stem cell phenotype: insights from cancer biology with therapeutic implications for colorectal cancer JO - Cancer Gene Ther VL - 21 UR - https://doi.org/10.1038/cgt.2014.15 DO - 10.1038/cgt.2014.15 ID - Findlay2014 ER - TY - JOUR AU - Okuda, H. AU - Kobayashi, A. AU - Xia, B. AU - Watabe, M. AU - Pai, S. K. AU - Hirota, S. PY - 2012 DA - 2012// TI - Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells JO - Cancer Res VL - 72 UR - https://doi.org/10.1158/0008-5472.CAN-11-1678 DO - 10.1158/0008-5472.CAN-11-1678 ID - Okuda2012 ER - TY - JOUR AU - Seol, M. A. AU - Chu, I. S. AU - Lee, M. J. AU - Yu, G. R. AU - Cui, X. D. AU - Cho, B. H. PY - 2011 DA - 2011// TI - Genome-wide expression patterns associated with oncogenesis and sarcomatous transdifferentation of cholangiocarcinoma JO - BMC Cancer VL - 11 UR - https://doi.org/10.1186/1471-2407-11-78 DO - 10.1186/1471-2407-11-78 ID - Seol2011 ER - TY - JOUR AU - Tchaicha, J. H. AU - Reyes, S. B. AU - Shin, J. AU - Hossain, M. G. AU - Lang, F. F. AU - McCarty, J. H. PY - 2011 DA - 2011// TI - Glioblastoma angiogenesis and tumor cell invasiveness are differentially regulated by beta8 integrin JO - Cancer Res VL - 71 UR - https://doi.org/10.1158/0008-5472.CAN-11-0991 DO - 10.1158/0008-5472.CAN-11-0991 ID - Tchaicha2011 ER - TY - JOUR AU - Xu, D. AU - McKee, C. M. AU - Cao, Y. AU - Ding, Y. AU - Kessler, B. M. AU - Muschel, R. J. PY - 2010 DA - 2010// TI - Matrix metalloproteinase-9 regulates tumor cell invasion through cleavage of protease nexin-1 JO - Cancer Res VL - 70 UR - https://doi.org/10.1158/0008-5472.CAN-10-0242 DO - 10.1158/0008-5472.CAN-10-0242 ID - Xu2010 ER - TY - JOUR AU - Kalluri, R. AU - Zeisberg, M. PY - 2006 DA - 2006// TI - Fibroblasts in cancer JO - Nat Rev Cancer VL - 6 UR - https://doi.org/10.1038/nrc1877 DO - 10.1038/nrc1877 ID - Kalluri2006 ER - TY - JOUR AU - Mokkapati, S. AU - Bechtel, M. AU - Reibetanz, M. AU - Miosge, N. AU - Nischt, R. PY - 2012 DA - 2012// TI - Absence of the basement membrane component nidogen 2, but not of nidogen 1, results in increased lung metastasis in mice JO - J Histochem Cytochem VL - 60 ID - Mokkapati2012 ER - TY - JOUR AU - Williams, M. D. AU - Zhang, L. AU - Elliott, D. D. AU - Perrier, N. D. AU - Lozano, G. AU - Clayman, G. L. PY - 2011 DA - 2011// TI - Differential gene expression profiling of aggressive and nonaggressive follicular carcinomas JO - Hum Pathol VL - 42 UR - https://doi.org/10.1016/j.humpath.2010.12.006 DO - 10.1016/j.humpath.2010.12.006 ID - Williams2011 ER - TY - JOUR AU - Zhang, H. AU - Kim, J. K. AU - Edwards, C. A. AU - Xu, Z. AU - Taichman, R. AU - Wang, C. Y. PY - 2005 DA - 2005// TI - Clusterin inhibits apoptosis by interacting with activated Bax JO - Nat Cell Biol VL - 7 UR - https://doi.org/10.1038/ncb1291 DO - 10.1038/ncb1291 ID - Zhang2005 ER - TY - JOUR AU - Spengler, D. AU - Villalba, M. AU - Hoffmann, A. AU - Pantaloni, C. AU - Houssami, S. AU - Bockaert, J. PY - 1997 DA - 1997// TI - Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain JO - EMBO J VL - 16 UR - https://doi.org/10.1093/emboj/16.10.2814 DO - 10.1093/emboj/16.10.2814 ID - Spengler1997 ER - TY - JOUR AU - Nam, J. S. AU - Kang, M. J. AU - Suchar, A. M. AU - Shimamura, T. AU - Kohn, E. A. AU - Michalowska, A. M. PY - 2006 DA - 2006// TI - Chemokine (C-C motif) ligand 2 mediates the prometastatic effect of dysadherin in human breast cancer cells JO - Cancer Res VL - 66 UR - https://doi.org/10.1158/0008-5472.CAN-06-0825 DO - 10.1158/0008-5472.CAN-06-0825 ID - Nam2006 ER - TY - JOUR AU - Zhang, J. AU - Lu, Y. AU - Pienta, K. J. PY - 2010 DA - 2010// TI - Multiple roles of chemokine (C-C motif) ligand 2 in promoting prostate cancer growth JO - J Natl Cancer Inst VL - 102 UR - https://doi.org/10.1093/jnci/djq044 DO - 10.1093/jnci/djq044 ID - Zhang2010 ER - TY - JOUR AU - Liao, R. AU - Sun, T. W. AU - Yi, Y. AU - Wu, H. AU - Li, Y. W. AU - Wang, J. X. PY - 2012 DA - 2012// TI - Expression of TREM-1 in hepatic stellate cells and prognostic value in hepatitis B-related hepatocellular carcinoma JO - Cancer Sci VL - 103 UR - https://doi.org/10.1111/j.1349-7006.2012.02273.x DO - 10.1111/j.1349-7006.2012.02273.x ID - Liao2012 ER - TY - JOUR AU - Sharpe, J. C. AU - Abel, P. D. AU - Gilbertson, J. A. AU - Brawn, P. AU - Foster, C. S. PY - 1994 DA - 1994// TI - Modulated expression of human leucocyte antigen class I and class II determinants in hyperplastic and malignant human prostatic epithelium JO - Br J Urol VL - 74 UR - https://doi.org/10.1111/j.1464-410X.1994.tb09193.x DO - 10.1111/j.1464-410X.1994.tb09193.x ID - Sharpe1994 ER - TY - JOUR AU - Reubi, J. C. AU - Gugger, M. AU - Waser, B. AU - Schaer, J. C. PY - 2001 DA - 2001// TI - Y(1)-mediated effect of neuropeptide Y in cancer: breast carcinomas as targets JO - Cancer Res VL - 61 ID - Reubi2001 ER - TY - JOUR AU - Kitlinska, J. AU - Abe, K. AU - Kuo, L. AU - Pons, J. AU - Yu, M. AU - Li, L. PY - 2005 DA - 2005// TI - Differential effects of neuropeptide Y on the growth and vascularization of neural crest-derived tumors JO - Cancer Res VL - 65 UR - https://doi.org/10.1158/0008-5472.CAN-04-2192 DO - 10.1158/0008-5472.CAN-04-2192 ID - Kitlinska2005 ER - TY - JOUR AU - Florio, M. AU - Hernandez, M. C. AU - Yang, H. AU - Shu, H. K. AU - Cleveland, J. L. AU - Israel, M. A. PY - 1998 DA - 1998// TI - Id2 promotes apoptosis by a novel mechanism independent of dimerization to basic helix-loop-helix factors JO - Mol Cell Biol VL - 18 UR - https://doi.org/10.1128/MCB.18.9.5435 DO - 10.1128/MCB.18.9.5435 ID - Florio1998 ER - TY - JOUR AU - Ge, Y. L. AU - Zhang, X. AU - Zhang, J. Y. AU - Hou, L. AU - Tian, R. H. PY - 2009 DA - 2009// TI - The mechanisms on apoptosis by inhibiting VEGF expression in human breast cancer cells JO - Int Immunopharmacol VL - 9 UR - https://doi.org/10.1016/j.intimp.2008.11.020 DO - 10.1016/j.intimp.2008.11.020 ID - Ge2009 ER - TY - JOUR AU - Cheng, J. C. AU - Chang, H. M. AU - Leung, P. C. PY - 2013 DA - 2013// TI - Egr-1 mediates epidermal growth factor-induced downregulation of E-cadherin expression via Slug in human ovarian cancer cells JO - Oncogene VL - 32 UR - https://doi.org/10.1038/onc.2012.127 DO - 10.1038/onc.2012.127 ID - Cheng2013 ER - TY - JOUR AU - Liu, C. AU - Adamson, E. AU - Mercola, D. PY - 1996 DA - 1996// TI - Transcription factor EGR-1 suppresses the growth and transformation of human HT-1080 fibrosarcoma cells by induction of transforming growth factor beta 1 JO - Proc Natl Acad Sci U S A VL - 93 UR - https://doi.org/10.1073/pnas.93.21.11831 DO - 10.1073/pnas.93.21.11831 ID - Liu1996 ER - TY - JOUR AU - Su, L. AU - Cheng, H. AU - Sampaio, A. V. AU - Nielsen, T. O. AU - Underhill, T. M. PY - 2010 DA - 2010// TI - EGR1 reactivation by histone deacetylase inhibitors promotes synovial sarcoma cell death through the PTEN tumor suppressor JO - Oncogene VL - 29 UR - https://doi.org/10.1038/onc.2010.204 DO - 10.1038/onc.2010.204 ID - Su2010 ER - TY - JOUR AU - Bufalo, D. AU - Castro, V. AU - Biroccio, A. AU - Varmi, M. AU - Salani, D. AU - Rosano, L. PY - 2002 DA - 2002// TI - Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis: requirement for Akt activation JO - Mol Pharmacol VL - 61 UR - https://doi.org/10.1124/mol.61.3.524 DO - 10.1124/mol.61.3.524 ID - Bufalo2002 ER - TY - JOUR AU - Liu, P. Y. AU - Hsieh, T. Y. AU - Liu, S. T. AU - Chang, Y. L. AU - Lin, W. S. AU - Wang, W. M. PY - 2011 DA - 2011// TI - Zac1, an Sp1-like protein, regulates human p21(WAF1/Cip1) gene expression in HeLa cells JO - Exp Cell Res VL - 317 UR - https://doi.org/10.1016/j.yexcr.2011.09.018 DO - 10.1016/j.yexcr.2011.09.018 ID - Liu2011 ER - TY - JOUR AU - Kaluza, D. AU - Kroll, J. AU - Gesierich, S. AU - Manavski, Y. AU - Boeckel, J. N. AU - Doebele, C. PY - 2013 DA - 2013// TI - Histone deacetylase 9 promotes angiogenesis by targeting the antiangiogenic microRNA-17-92 cluster in endothelial cells JO - Arterioscler Thromb Vasc Biol VL - 33 UR - https://doi.org/10.1161/ATVBAHA.112.300415 DO - 10.1161/ATVBAHA.112.300415 ID - Kaluza2013 ER - TY - JOUR AU - Comer, K. A. AU - Dennis, P. A. AU - Armstrong, L. AU - Catino, J. J. AU - Kastan, M. B. AU - Kumar, C. C. PY - 1998 DA - 1998// TI - Human smooth muscle alpha-actin gene is a transcriptional target of the p53 tumor suppressor protein JO - Oncogene VL - 16 UR - https://doi.org/10.1038/sj.onc.1201645 DO - 10.1038/sj.onc.1201645 ID - Comer1998 ER - TY - JOUR AU - Januchowski, R. AU - Zawierucha, P. AU - Andrzejewska, M. AU - Rucinski, M. AU - Zabel, M. PY - 2013 DA - 2013// TI - Microarray-based detection and expression analysis of ABC and SLC transporters in drug-resistant ovarian cancer cell lines JO - Biomed Pharmacother VL - 67 UR - https://doi.org/10.1016/j.biopha.2012.11.011 DO - 10.1016/j.biopha.2012.11.011 ID - Januchowski2013 ER - TY - JOUR AU - Bodoy, S. AU - Fotiadis, D. AU - Stoeger, C. AU - Kanai, Y. AU - Palacin, M. PY - 2013 DA - 2013// TI - The small SLC43 family: facilitator system l amino acid transporters and the orphan EEG1 JO - Mol Aspects Med VL - 34 UR - https://doi.org/10.1016/j.mam.2012.12.006 DO - 10.1016/j.mam.2012.12.006 ID - Bodoy2013 ER - TY - JOUR AU - Draheim, K. M. AU - Chen, H. B. AU - Tao, Q. AU - Moore, N. AU - Roche, M. AU - Lyle, S. PY - 2010 DA - 2010// TI - ARRDC3 suppresses breast cancer progression by negatively regulating integrin beta4 JO - Oncogene VL - 29 UR - https://doi.org/10.1038/onc.2010.250 DO - 10.1038/onc.2010.250 ID - Draheim2010 ER - TY - JOUR AU - Yang, Z. AU - Chen, H. AU - Huo, L. AU - Yang, Z. AU - Bai, Y. AU - Fan, X. PY - 2015 DA - 2015// TI - Epigenetic inactivation and tumor-suppressor behavior of NGFR in human colorectal cancer JO - Mol Cancer Res VL - 13 UR - https://doi.org/10.1158/1541-7786.MCR-13-0247 DO - 10.1158/1541-7786.MCR-13-0247 ID - Yang2015 ER - TY - JOUR AU - Kuang, S. Q. AU - Tong, W. G. AU - Yang, H. AU - Lin, W. AU - Lee, M. K. AU - Fang, Z. H. PY - 2008 DA - 2008// TI - Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia JO - Leukemia VL - 22 UR - https://doi.org/10.1038/leu.2008.130 DO - 10.1038/leu.2008.130 ID - Kuang2008 ER -