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Table 4 Average miRNAs fold change values in pancreatic cancers in comparison with normal tissues

From: Small nucleolar RNA U91 is a new internal control for accurate microRNAs quantification in pancreatic cancer

miRNAs Internal controls
Spike U6 miR-16 U91 U6 + U91
miR-21 14.56 ± 6.468; p< 0.01 5.44 ± 2.73; p< 0.01 7,03 ± 3,614; p< 0.01 17.71 ± 11.922; p< 0.01 9.67 ± 6.287; p< 0.01
miR-96 −1.04 ± 0.668; p > 0.05 −3.22 ± 1.766; p< 0.01 −2,32 ± 1.376; p< 0.01 −1.17 ± 0.831; p > 0.05 −1.85 ± 1.134; p< 0.01
miR-148a 1.25 ± 0.429; p > 0.05 −2.04 ± 0.92; p< 0.01 −1.33 ± 0.782; p< 0.05 1.06 ± 0.549; p > 0.05 −1.27 ± 0.594; p > 0.05
miR-155 15.1 ± 8.786; p< 0.01 5.05 ± 2.992; p< 0.01 6.39 ± 3.312; p< 0.01 13.36 ± 9.477; p< 0.01 8.79 ± 5.675; p< 0.01
miR-196a 1.09 ± 0.306; p > 0.05 −2.22 ± 1.09; p< 0.01 −1.35 ± 0.905; p > 0.05 1.13 ± 0.676; p > 0.05 −1.34 ± 0.726; p< 0.05
miR-217 −8.69 ± 4.99; p< 0.01 −24,39 ± 13.616; p< 0.01 −16.39 ± 9.71; p< 0.01 −9.09 ± 5.323; p< 0.01 −7.19 ± 4.161; p< 0.01
  1. MicroRNAs expression was measured relative to four different internal controls and combination of two of them (U6 + U91). Negative fold change values indicate downregulation of the miRNAs in cancer samples. Data are presented as means ± standard deviation (SD). p < 0.05 is considered as statistically significant. P values of the Student’s t-test for the significant differences are shown in bold