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Table 4 Average miRNAs fold change values in pancreatic cancers in comparison with normal tissues

From: Small nucleolar RNA U91 is a new internal control for accurate microRNAs quantification in pancreatic cancer

miRNAs

Internal controls

Spike

U6

miR-16

U91

U6 + U91

miR-21

14.56 ± 6.468; p< 0.01

5.44 ± 2.73; p< 0.01

7,03 ± 3,614; p< 0.01

17.71 ± 11.922; p< 0.01

9.67 ± 6.287; p< 0.01

miR-96

−1.04 ± 0.668; p > 0.05

−3.22 ± 1.766; p< 0.01

−2,32 ± 1.376; p< 0.01

−1.17 ± 0.831; p > 0.05

−1.85 ± 1.134; p< 0.01

miR-148a

1.25 ± 0.429; p > 0.05

−2.04 ± 0.92; p< 0.01

−1.33 ± 0.782; p< 0.05

1.06 ± 0.549; p > 0.05

−1.27 ± 0.594; p > 0.05

miR-155

15.1 ± 8.786; p< 0.01

5.05 ± 2.992; p< 0.01

6.39 ± 3.312; p< 0.01

13.36 ± 9.477; p< 0.01

8.79 ± 5.675; p< 0.01

miR-196a

1.09 ± 0.306; p > 0.05

−2.22 ± 1.09; p< 0.01

−1.35 ± 0.905; p > 0.05

1.13 ± 0.676; p > 0.05

−1.34 ± 0.726; p< 0.05

miR-217

−8.69 ± 4.99; p< 0.01

−24,39 ± 13.616; p< 0.01

−16.39 ± 9.71; p< 0.01

−9.09 ± 5.323; p< 0.01

−7.19 ± 4.161; p< 0.01

  1. MicroRNAs expression was measured relative to four different internal controls and combination of two of them (U6 + U91). Negative fold change values indicate downregulation of the miRNAs in cancer samples. Data are presented as means ± standard deviation (SD). p < 0.05 is considered as statistically significant. P values of the Student’s t-test for the significant differences are shown in bold