Table 2 Univariate and multivariate analyses of clinicopathologic variables affecting A: RFS and B: OS in patients with stage I-III CRC
From: Prognostic significance of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer
Variables | No. Patients | Univariate analysis | Multivariate analysis | |||
Hazard ratio (95 % CI) | p value | Hazard ratio (95 % CI) | p value | |||
≪RFS≫ | ||||||
 Age | < 70 years | 151 | 0.614 (0.377–0.988) | 0.049 | 1.849 (1.115–3.067) | 0.017 |
≥ 70 years | 69 | |||||
 Gender | male | 148 | 1.709 (0.974–2.996) | 0.062 | ||
female | 72 | |||||
 Histology (TNM 7th) | G1 | 90 | 0.485 (0.285–0.826) | 0.008 | 1.555 (0.884–2.737) | 0.125 |
G2, G3 | 130 | |||||
 Tumor location | colon | 134 | 1.473 (0.911–2.382) | 0.114 | ||
rectum | 86 | |||||
 Depth of tumor invasion (TNM 7th) | T1-3 | 153 | 2.713 (1.342–3.520) | 0.002 | 1.061 (0.616–1.827) | 0.832 |
T4 | 67 | |||||
 Lymphatic invasion | (-) | 67 | 2.647 (1.386–5.054) | 0.003 | 1.344 (0.643–2.809) | 0.432 |
(+) | 153 | |||||
 Venous invasion | (-) | 33 | 3.260 (1.186–8.959) | 0.022 | 1.334 (0.457–3.893) | 0.598 |
(+) | 187 | |||||
 Lymph node metastasis | (-) | 135 | 3.316 (2.018–5.447) | < 0.001 | 2.326 (1.276–4.243) | 0.006 |
(+) | 85 | |||||
 CEA | < 5 ng/ml | 153 | 2.239 (1.379–3.634) | 0.001 | 1.498 (0.907–2.473) | 0.114 |
≥ 5 ng/ml | 67 | |||||
 TNIK expression | low | 139 | 2.762 (1.694–4.502) | < 0.001 | 2.184 (1.310–3.641) | 0.003 |
high | 81 | |||||
Variables | No. Patients | Univariate analysis | Multivariate analysis | |||
Hazard ratio (95 % CI) | p value | Hazard ratio (95 % CI) | p value | |||
≪OS≫ | ||||||
 Age | < 70 years | 151 | 2.842 (1.589–5.083) | < 0.001 | 2.887 (1.559–5.343) | 0.001 |
≥ 70 years | 69 | |||||
 Gender | male | 148 | 0.451 (0.218–0.936) | 0.032 | 0.598 (0.281–1.272) | 0.182 |
female | 72 | |||||
 Histology (TNM 7th) | G1 | 90 | 2.046 (1.076–3.889) | 0.029 | 1.572 (0.788–3.137) | 0.199 |
G2, G3 | 130 | |||||
 Tumor location | colon | 134 | 1.301 (0.726–2.332) | 0.376 | ||
rectum | 86 | |||||
 Depth of tumor invasion (TNM 7th) | T1-3 | 153 | 3.047 (1.706–5.440) | < 0.001 | 1.693 (0.865–3.314) | 0.124 |
T4 | 67 | |||||
 Lymphatic invasion | (-) | 67 | 2.368 (1.104–5.077) | 0.027 | 1.226 (0.517–2.909) | 0.643 |
(+) | 153 | |||||
 Venous invasion | (-) | 33 | 4.483 (1.086–18.500) | 0.038 | 1.709 (0.385–7.591) | 0.481 |
(+) | 187 | |||||
 Lymph node metastasis | (-) | 135 | 2.582 (1.435–4.648) | 0.002 | 1.505 (0.733–3.093) | 0.266 |
(+) | 85 | |||||
 CEA | < 5 ng/ml | 153 | 2.608 (1.461–4.657) | 0.001 | 1.692 (0.929–3.082) | 0.086 |
≥ 5 ng/ml | 67 | |||||
 TNIK expression | low | 139 | 3.373 (1.838–6.192) | < 0.001 | 2.279 (1.205–4.310) | 0.011 |
high | 81 | |||||