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Table 2 Univariate and multivariate analyses of clinicopathologic variables affecting A: RFS and B: OS in patients with stage I-III CRC

From: Prognostic significance of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer

Variables   No. Patients Univariate analysis Multivariate analysis
Hazard ratio (95 % CI) p value Hazard ratio (95 % CI) p value
RFS
 Age < 70 years 151 0.614 (0.377–0.988) 0.049 1.849 (1.115–3.067) 0.017
≥ 70 years 69
 Gender male 148 1.709 (0.974–2.996) 0.062   
female 72
 Histology (TNM 7th) G1 90 0.485 (0.285–0.826) 0.008 1.555 (0.884–2.737) 0.125
G2, G3 130
 Tumor location colon 134 1.473 (0.911–2.382) 0.114   
rectum 86
 Depth of tumor invasion (TNM 7th) T1-3 153 2.713 (1.342–3.520) 0.002 1.061 (0.616–1.827) 0.832
T4 67
 Lymphatic invasion (-) 67 2.647 (1.386–5.054) 0.003 1.344 (0.643–2.809) 0.432
(+) 153
 Venous invasion (-) 33 3.260 (1.186–8.959) 0.022 1.334 (0.457–3.893) 0.598
(+) 187
 Lymph node metastasis (-) 135 3.316 (2.018–5.447) < 0.001 2.326 (1.276–4.243) 0.006
(+) 85
 CEA < 5 ng/ml 153 2.239 (1.379–3.634) 0.001 1.498 (0.907–2.473) 0.114
≥ 5 ng/ml 67
 TNIK expression low 139 2.762 (1.694–4.502) < 0.001 2.184 (1.310–3.641) 0.003
high 81
Variables   No. Patients Univariate analysis Multivariate analysis
Hazard ratio (95 % CI) p value Hazard ratio (95 % CI) p value
OS
 Age < 70 years 151 2.842 (1.589–5.083) < 0.001 2.887 (1.559–5.343) 0.001
≥ 70 years 69
 Gender male 148 0.451 (0.218–0.936) 0.032 0.598 (0.281–1.272) 0.182
female 72
 Histology (TNM 7th) G1 90 2.046 (1.076–3.889) 0.029 1.572 (0.788–3.137) 0.199
G2, G3 130
 Tumor location colon 134 1.301 (0.726–2.332) 0.376   
rectum 86
 Depth of tumor invasion (TNM 7th) T1-3 153 3.047 (1.706–5.440) < 0.001 1.693 (0.865–3.314) 0.124
T4 67
 Lymphatic invasion (-) 67 2.368 (1.104–5.077) 0.027 1.226 (0.517–2.909) 0.643
(+) 153
 Venous invasion (-) 33 4.483 (1.086–18.500) 0.038 1.709 (0.385–7.591) 0.481
(+) 187
 Lymph node metastasis (-) 135 2.582 (1.435–4.648) 0.002 1.505 (0.733–3.093) 0.266
(+) 85
 CEA < 5 ng/ml 153 2.608 (1.461–4.657) 0.001 1.692 (0.929–3.082) 0.086
≥ 5 ng/ml 67
 TNIK expression low 139 3.373 (1.838–6.192) < 0.001 2.279 (1.205–4.310) 0.011
high 81
  1. CI confidence interval