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Table 2 Retinoblastoma in relation to maternal medical conditions and prescription drug use

From: A case–control study of sporadic retinoblastoma in relation to maternal health conditions and reproductive factors: a report from the Children’s Oncology group

  Controls (n = 136) Unilateral cases (n = 165) Bilateral cases (n = 87)
   Crudea Adjustedb   Crudea Adjustedb
Medical conditions N (%) N (%) OR OR (95 % CI) N (%) OR OR (95 % CI)
Any medical condition 74 (47.7) 115 (61.5) 1.6 1.5 (0.9, 2.6) 57 (60.0) 1.6 1.2 (0.7, 2.3)
Infectious diseases        
 Any infectious disease 32 (20.7) 44 (23.6) 1.1 1.0 (0.5, 1.7) 19 (20.0) 0.8 0.8 (0.4, 1.6)
 Respiratory infection 18 (11.6) 21 (11.2) 1.0 0.9 (0.4, 2.0) 7 (7.4) 0.5 0.4 (0.1, 1.2)
 Flu or cold 10 (6.5) 17 (9.1) 1.4 1.2 (0.5, 3.1) 3 (3.4) 0.4 0.3 (0.1, 1.4)
 Other viral infections 1 (0.7) 5 (2.7) 3.8 3.6 (0.3, 47.9) 2 (2.1) 2.2 3.7 (0.3, 3.5)
 Sexually transmitted infections 0 (0.0) 1 (0.5) - - 1 (1.1) - -
 All bacterial infections 18 (11.6) 24 (12.8) 1.1 1.1 (0.5, 2.4) 11 (11.6) 0.9 0.8 (0.3, 2.1)
 Urinary tract infections 6 (3.9) 9 (4.8) 1.1 0.8 (0.2, 3.0) 1 (1.1) 0.1 0.2 (0.1, 1.8)
 Mother took antibiotics in pregnancy 21 (13.6) 22 (11.8) 0.8 0.8 (0.3, 1.8) 10 (10.5) 0.6 0.5 (0.2, 1.4)
Chronic diseases        
 High blood pressure 17 (11.0) 23 (12.3) 1.1 1.2 (0.5, 2.6) 11 (11.6) 1.2 1.0 (0.4, 2.6)
 Gestational high blood pressure 17 (11.0) 22 (11.8) 1.1 1.1 (0.5, 2.5) 11 (11.6) 1.2 1.0 (0.4, 2.6)
 Diabetes (any) 6 (3.9) 17 (9.1) 2.5 2.2 (0.8, 6.6) 8 (8.4) 1.8 1.9 (0.6, 6.6)
 Gestational diabetes 6 (3.9) 14 (7.5) 2.0 1.9 (0.6. 5.7) 8 (8.4) 1.8 1.9 (0.6, 6.6)
 Preeclampsia 7 (4.5) 9 (4.8) 1.1 1.1 (0.3, 4.4) 2 (2.1) 0.7 0.6 (0.1, 4.0)
Endocrine disorders        
 Any thyroid problem 2 (1.3) 6 (3.2) 2.2 2.2 (0.4, 12.3) 2 (2.1) 1.0 0.8 (0.1, 7.5)
 Hypothyroidism 2 (1.3) 5 (2.7) 1.6 1.6 (0.3, 9.6) 2 (2.1) 1.0 0.8 (0.1, 7.4)
Pain and pain medication        
 Back pain 4 (2.6) 11 (5.9) 2.5 3.4 (0.8, 14.4) 4 (4.2) 2.2 2.0 (0.3, 13.9)
 Pain medication 3 (1.9) 8 (4.3) 2.3 4.2 (0.8, 23.3) 7 (7.4) 6.0 9.0 (1.4, 56.4)
Other Diseases and conditions        
 Depression/anxiety 5 (3.2) 10 (5.4) 2.2 3.3 (0.7, 14.8) 5 (5.3) 2.3 3.8 (0.7, 21.8)
 Anemia 1 (0.7) 6 (3.2) 4.5 2.8 (0.3, 27.0) 2 (2.1) 2.2 1.1 (0.1, 16.1)
 Allergy/asthma 8 (5.2) 13 (7.0) 1.3 1.3 (0.5, 3.7) 7 (7.4) 1.3 1.7 (0.5, 5.9)
  1. aAdjusted for the matching variable, child’s age at interview
  2. bAdjusted for child age at interview, mother’s race/ethnicity, mother’s educational attainment, household income, mother’s age at birth, and maternal smoking in the month before or during pregnancy