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Table 2 Distribution of cases of urothelial carcinoma of the bladder (UCB) and controls, odds ratio (OR) and corresponding 95 % confidence interval (CI), according to indicators of metabolic syndrome (MetS). Italy, 2003-2014

From: Metabolic syndrome and the risk of urothelial carcinoma of the bladder: a case-control study

Components

UCB Cases

Controls

OR (95 % CI)a

OR (95 % CI)b

n

(%)

n

(%)

Diabetes mellitus

      

  No

443

(83.1)

435

(92.0)

Ref

Ref

  Yes

90

(16.9)

38

(8.0)

2.22 (1.45-3.39)

2.20 (1.42-3.38)

Drug-treated hypertension

     

  No

316

(59.3)

279

(59.0)

Ref

Ref

  Yes

217

(40.7)

194

(41.0)

0.99 (0.75-1.31)

0.88 (0.66-1.17)

Drug-treated hyperlipidaemia

   

  No

442

(82.9)

399

(84.4)

Ref

Ref

  Yes

91

(17.1)

74

(15.6)

1.21 (0.84-1.73)

1.16 (0.80-1.67)

Abdominal obesityc

      

  No

145

(27.2)

167

(35.3)

Ref

Ref

  Yes

388

(72.8)

306

(64.7)

1.65 (1.23-2.21)

1.63 (1.22-2.19)

Nr. of MetS components

   

  None

83

(15.6)

85

(18.0)

Ref

 

  1

213

(40.0)

208

(44.0)

1.03 (0.70-1.51)

 

  2

154

(28.9)

138

(29.2)

1.23 (0.81-1.85)

 

  3

67

(12.6)

40

(8.5)

2.00 (1.17-3.41)

 

  4

16

(3.0)

2

(0.4)

7.93 (1.71-36.79)

 

  χ2 for trend; p-value

    

11.45; P < 0.01

 

Increment of 1 MetS component

  

1.29 (1.11-1.49)

 

Indicators of MetSd

      

  No

450

(84.4)

431

(91.1)

Ref

 

  Yes

83

(15.6)

42

(8.9)

2.09 (1.38-3.19)

 

  "Without diabetes"

29

(5.4)

26

(5.5)

1.16 (0.65-2.07)

 

  "With diabetes"

54

(10.1)

16

(3.4)

3.63 (1.99-6.61)

 
  1. aAdjusted for sex, age (<55; 55-59; 60-64; 65-69; 70-74; ≥75 years), study centre, education (<7; 7-11; ≥12 years), and tobacco smoking (never; former; current: <20; 20+ cigarettes/day); bSeparate components were additionally adjusted for the other MetS components; cAccording to IDF cut-points for waist circumference. dDefined as the presence of at least three out of four MetS components