Fig. 2

Results of circulating Th subsets in HC, CIN and CC patients. a The percentages of circulating Th22 (CD4⁺IFNγ⁻IL17ˉIL22⁺ T cells) cells. Significantly higher percentage of Th22 cells was present in CC patients (1.75 ± 0.704 %) in comparison with CIN patients (1.27 ± 0.56 %, p < 0.001) and HC (0.77 ± 0.36 %, p < 0.001); again increased percentage of Th22 cells noticed in CIN patients than HC (p = 0.001). b The percentages of circulating pure Th17 (CD4⁺IFNγˉIL17⁺IL22ˉ T cells) cells. There was a significantly high percentage of pure Th17 cells in CIN patients (3.10 ± 1.40 %, p < 0.001) or CC patients (3.35 ± 1.34 %, p < 0.001) than HC (1.78 ± 0.80 %). c The percentages of circulating Th1 (CD4⁺IFNγ⁺ T cells) cells. Significantly elevated frequencies of Th1 cells were found in CC (7.95 % ± 3.95 %) compared with HC (4.98 % ± 2.92 %, p < 0.001) and CIN patients (6.23 % ± 2.52 %, p < 0.001). However, no significant difference was found between HC and CIN patients. d Correlation of Th17/Th22 ratio in HC, CIN and CC patients. Significant difference was found between CIN (3.09 ± 2.60) and CC patients (2.12 ± 1.02, p = 0.007). Bars symbolized SD. * p < 0.05, ** p < 0.01, *** p < 0.001. NS no significance