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Table 1 Clinical characteristics of discovery case 1 and 2

From: Whole exome sequencing of microdissected splenic marginal zone lymphoma: a study to discover novel tumor-specific mutations

Discovery case Sex Age at splenectomy B-Symptoms Leukemic disease (villous Lymphozytes) Immunophenotype Clinical staging at splenectomy Oncological responsea
1 f 59 yes no CD20+++, IgM-, Kappa-, Lambda-, Ki-67 5 %, CD5-, CD3-, Cyclin-D1-, bcl-2++ IV CR
2 f 59 yes no CD20+++, IgM+, Kappa-, Lambda-, Ki-67 15 %, CD5-, CD3-, Cyclin-D1-, bcl-2++ IV CR
  1. aafter splenectomy