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Table 4 Multivariate Cox-regression models applied to the adherence index and crucial risk, prognosis and predictive factors

From: The adherence paradox: guideline deviations contribute to the increased 5-year survival of breast cancer patients

Regressors Beta Standard Test Hazard- 95 % confidence interval
coefficient error P-value ratio Lower bound Upper bound
Cohort 1996–97, Institutional-invasive sample
 Adherence index −0.373 0.436 0.392 0.688 0.293 1.619
 Age at surgery −0.044 0.069 0.525 0.957 0.836 1.069
 Nodal status (pN-, pN+) 1.049 0.263 <0.001 2.854 1.706 4.775
 Tumor size (pT2, pT2-pT4) 0.121 0.244 0.620 1.129 0.700 1.821
 Hormon receptor status (ERPR+, ERPR-) 0.602 0.313 0.055 1.825 0.988 3.371
 Quadratic term of age at surgery 0.001 0.001 0.132 1.001 1.000 1.002
Cohort 1996–97, Regional-invasive sample
 Adherence index −0.162 0.489 0.740 0.850 0.326 2.217
 Age at surgery −0.058 0.083 0.483 0.943 0.801 1.111
 Nodal status (pN-, pN+) 1.184 0.336 <0.001 3.269 1.692 6.316
 Tumor size (pT2, pT2-pT4) 0.015 0.307 0.961 1.015 0.556 1.854
 Hormon receptor status (ERPR+, ERPR-) 0.664 0.389 0.088 1.942 0.907 4.162
 Quadratic term of age at surgery 0.001 0.001 0.188 1.001 1.000 1.002
Cohort 2003–04, Institutional-invasive sample
 Adherence index −0.135 0.350 0.699 0.873 0.440 1.733
 Age at surgery −0.089 0.080 0.266 0.915 0.782 1.070
 Nodal status (pN-, pN+) 0.931 0.307 0.002 2.537 1.391 4.627
 Tumor size (pT2, pT2-pT4) 0.615 0.302 0.042 1.850 1.023 3.344
 Hormon receptor status (ERPR+, ERPR-) 1.196 0.310 <0.001 3.307 1.801 6.075
 Quadratic term of age at surgery 0.001 0.001 0.173 1.001 1.000 1.002
Cohort 2003–04, Regional-invasive sample
 Adherence index −0.638 0.467 0.172 0.529 0.212 1.320
 Age at surgery −0.151 0.090 0.093 0.859 0.720 1.025
 Nodal status (pN-, pN+) 0.500 0.375 0.182 1.648 0.791 3.437
 Tumor size (pT2, pT2-pT4) 0.512 0.371 0.168 1.668 0.806 3.450
 Hormon receptor status (ERPR+, ERPR-) 1.048 0.367 0.004 2.853 1.389 5.861
 Quadratic term of age at surgery 0.001 0.001 0.070 1.001 1.000 1.003
  1. Legend: Confidence intervals (CI) with lower bounds (LB) and upper bounds (UB), planned chemotherapy (no, yes) and location of treatment (clinics A + B, C) were used as strata variables