Table 4 Cox multivariate analysis of GATA4 expression/promoter methylation and clinico-pathological features in pediatric AML
| Variable | Odds ratio | EXP(B) 95 % CI | P |
|---|---|---|---|
| Cytogenetics | |||
| Favo vs. Inter and Unfavo | 5.894 | 2.412 (1.185–4.909) | 0.015 |
| MRD | |||
| < 0.25 % vs. ≥0.25 % | 16.241 | 5.986 (2.503–14.229) | 0.000 |
| Leukocyte (/μl) | |||
| > 10,000 vs. ≤10,000 | 0.485 | 1.225 (0.691–2.172) | 0.486 |
| FAB classification | |||
| M7 vs. M1–M6 | 6.645 | 2.630 (1.261–5.484) | 0.010 |
| GATA4 Expression | |||
| Low vs. High | 2.765 | 1.657 (0.914–3.007) | 0.096 |
| GATA4 Methylation | |||
| Negative vs. Positive | 1.885 | 0.661 (0.367–1.193) | 0.170 |