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Table 4 Cox multivariate analysis of GATA4 expression/promoter methylation and clinico-pathological features in pediatric AML

From: Hypermethylation of the GATA binding protein 4 (GATA4) promoter in Chinese pediatric acute myeloid leukemia

Variable

Odds ratio

EXP(B) 95 % CI

P

Cytogenetics

 Favo vs. Inter and Unfavo

5.894

2.412 (1.185–4.909)

0.015

MRD

  < 0.25 % vs. ≥0.25 %

16.241

5.986 (2.503–14.229)

0.000

Leukocyte (/μl)

  > 10,000 vs. ≤10,000

0.485

1.225 (0.691–2.172)

0.486

FAB classification

 M7 vs. M1–M6

6.645

2.630 (1.261–5.484)

0.010

GATA4 Expression

 Low vs. High

2.765

1.657 (0.914–3.007)

0.096

GATA4 Methylation

 Negative vs. Positive

1.885

0.661 (0.367–1.193)

0.170