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Table 3 Association of GATA4 expression/promoter methylation with Kaplan-Meier survival in 105 pediatric AML samples

From: Hypermethylation of the GATA binding protein 4 (GATA4) promoter in Chinese pediatric acute myeloid leukemia

Variable

No. of patients

Over survival

P

Median ± SE

Cytogenetics

 Favorable

50

46.664 ± 3.717

<0.001

 Intermediate

27

29.220 ± 3.188

 

 Unfavorable

28

11.161 ± 1.827

 

FAB

 M1–M6

93

36.113 ± 2.885

<0.001

 M7

12

8.542 ± 1.820

 

Leukocyte (/μl)

  > 10,000

61

30.220 ± 2.974

0.803

  ≤ 10,000

44

33.631 ± 4.063

 

MRD

  < 0.25 %

49

53.627 ± 3.151

<0.001

  ≥ 0.25 %

56

18.893 ± 2.425

 

GATA4 expression

 Low <12.420

53

32.130 ± 3.385

0.769

 High ≥12.420

52

34.765 ± 3.941

 

GATA4 methylation

 Negative

46

39.141 ± 3.554

0.014

 Positive

59

24.264 ± 3.671

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