|
Mutant genes
|
Responders (CR + PR + SD)a vs non-responders
|
|---|
| |
Total responders
|
Total non-responders
|
Mutant responders
|
Mutant non-responders
|
P-valueb
|
|---|
|
KRAS
c
|
37
|
28
|
3
|
8
|
0.045
|
|
NRAS
|
37
|
28
|
1
|
1
|
0.999
|
|
BRAF
|
37
|
28
|
1
|
4
|
0.156
|
|
PI3KCA
|
37
|
28
|
2
|
4
|
0.389
|
|
FBXW7
|
37
|
28
|
1
|
5
|
0.077
|
|
SMAD4
|
37
|
28
|
1
|
4
|
0.156
|
|
NRAS/BRAF/PIK3CA
d
|
37
|
28
|
3
|
8
|
0.045
|
|
NRAS/BRAF/PIK3CA/FBXW7
d
|
37
|
28
|
4
|
11
|
0.016
|
|
NRAS/BRAF/PIK3CA/FBXW7/SMAD4
d
|
37
|
28
|
4
|
13
|
0.002
|
-
a
CR complete response, PR partial response, SD stable disease
-
b
P-value from Fisher's exact test
-
cPreviously undetected mutations
-
dSamples with mutations in at least one of the indicated genes
