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Fig. 3 | BMC Cancer

Fig. 3

From: Prediction of response to anti-EGFR antibody-based therapies by multigene sequencing in colorectal cancer patients

Fig. 3

Gene mutation diagram. Position of mutations found in KRAS, NRAS, BRAF, PIK3CA, FBXW7, and SMAD4 proteins. Red circles indicate the position of mutations within protein domains, which are responsible for protein-protein interactions or enzymatic activities. RBD, Raf-like Ras-binding domain; C1_1, phorbol esters/diacylglycerol binding domain (C1 domain); Pkinase_Tyr, protein tyrosine kinase; PI3K_p85B, PI3-kinase family, p85-binding domain; PI3K_rbd, PI3-kinase family, ras-binding domain; PI3K_C2, phosphoinositide 3-kinase C2; PI3Ka, phosphoinositide 3-kinase family, accessory domain (PIK domain); PI3_PI4_kinase, phosphatidylinositol 3- and 4-kinase; WD40, WD domain, G-beta repeat

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