Table 2 Clinical response after 1st line chemotherapy
|  | ITT popuration (n = 90) | KRAS wild type | KRAS mutant | |||
|---|---|---|---|---|---|---|
| Â | p53 antibody | p53 antibody | p53 antibody | |||
| Â | Positive | Negative | Positive | Negative | Positive | Negative |
n (%) | n = 36 | (n = 54) | (n = 11) | (n = 31) | (n = 13) | (n = 13) |
Complete Response | 5(13.8) | 2(3.7) | 1(9) | 1(3.2) | 3(23) | 0(0) |
Partial Response (PR) | 21(58.3) | 41(74.0) | 9(81.8) | 25(80.6) | 7(53.8) | 9(69.2) |
Stable Disease | 5(5.5) | 10(18.5) | 1(9) | 3(9.7) | 3(23) | 4(30.7) |
Progressive Disease | 2(8.3) | 1(1.8) | 0(0) | 1(3.2) | 0(0) | 0(0) |
Not Evaluable | 3(8.3) | 0(0) | 0(0) | 1(3.2) | 0(0) | 0(0) |
PR in | 26(72.2) | 43(79.6) | 10(91) | 26(83.8) | 10(76.9) | 9(69.2) |
Odds ratio (95 % CI) | 1.1 (0.55–2.21) | 0.92 (0.3–2.8) | 0.9 (0.23–3.43) | |||
P value | 0.87 | 1 | 1 | |||