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Table 3 Assessment of risk of bias of included cohort studies

From: Evaluation of the prognostic impact of postoperative adjuvant radiotherapy on head and neck mucosal melanoma: a meta-analysis

Criteria Jethanamest D Benlyazid A Owens JM Krengli M Meleti M Temam S
  (2011) [6] (2010) [11] (2003) [16] (2006) [14] (2008) [21] (2005) [15]
Any criteria descriptions for the patients yes yes yes yes yes yes
The representativeness of the surgery only group yes yes yes yes yes yes
The representativeness of the postoperative radiotherapy group yes yes yes yes yes yes
Group comparable for: yes yes yes yes yes yes
a.average age b.negative margin c patinet status
Group comparable for: unclear unclear unclear unclear unclear unclear
a.tumor site b.radiotherapy plan c.tumor stage
Control for confounding at each outcome(OS)a yes yes no unclear no unclear
Control for confounding at each outcome(LR)a unclear yes no yes no unclear
Control for confounding at each outcome(DM)a unclear yes no unclear no unclear
Blinding of participants at each outcome yes yes yes yes yes yes
Ascertainment of intervention exposure yes yes yes yes yes yes
Blinding of outcome assessment at each outcome yes yes yes yes yes yes
Ascertainment of outcome data yes yes yes yes yes yes
Was follow up long enough for outcomes to occur(OS) yes yes yes no yes yes
Was follow up long enough for outcomes to occur(LR) no yes yes yes no yes
Was follow up long enough for outcomes to occur(DM) no yes yes no no yes
Adequacy of follow up of cohorts unclear unclear unclear unclear unclear unclear
Criteria Gal TJ Thariat J Roth TN Brandwein MS Cheng YF Sun CZ
(2011) [7] (2011) [10] (2010) [12] (1997) [17] (2007) [13] (2014) [20]
Any criteria descriptions for the patients yes yes yes yes yes yes
The representativeness of the surgery only group yes yes yes yes yes yes
The representativeness of the postoperative radiotherapy group yes yes yes yes yes yes
Group comparable for: yes yes yes yes yes yes
a.average age b.negative margin c patinet status
Group comparable for: unclear unclear unclear unclear unclear yes
a.tumor site b.radiotherapy plan c.tumor stage
Control for confounding at each outcome(OS)a yes no no no no yes
Control for confounding at each outcome(LR)a unclear no no no no unclear
Control for confounding at each outcome(DM)a unclear no no no no unclear
Blinding of participants at each outcome yes yes yes yes yes yes
Ascertainment of intervention exposure yes yes yes yes yes yes
Blinding of outcome assessment at each outcome yes yes yes yes yes yes
Ascertainment of outcome data yes yes yes yes yes yes
Was follow up long enough for outcomes to occur(OS) yes yes yes yes yes yes
Was follow up long enough for outcomes to occur(LR) no yes yes yes yes no
Was follow up long enough for outcomes to occur(DM) no yes yes yes yes no
Adequacy of follow up of cohorts unclear unclear unclear unclear unclear unclear
  1. OS overall survival time, LR local recurrence, DM distance metastasis
  2. aconfounding factors means other intervening measures that may effect the outcomes(eg. chemical therapy etc.)