Fig. 8

Oxalate-treated mice generated undifferentiated and highly aggressive tumors. H&E staining of two representative sections of both non-cancerous breast tissue (a and b) and breast mice tumor tissues (d and e), generated after treatment with oxalate, are shown. Panels c and f are enlargements of the areas delimited in panels b and e respectively. Panel f mitotic figures (arrowheads) and abnormal epithelial breast duct cells (arrow) are marked. A total of 13 tumors and of 13 non-tumor tissues were examined. In all cases, animals treated with oxalate generated malignant, undifferentiated tumors with the characteristics of fibrosarcoma of the breast. Scale bar 50 μm