Fig. 4

BRCA1 expression as factor in relapse prediction models. Performances of two models are compared: the first model (solid line) includes BRCA1 expression parameters mRNA, protein expression and BARD1-ligated BRCA1, in addition to the three previously used conventional prognostic factors for breast cancer: tumor size, node invasion, CK5/6 expression. The second model (dash line) is composed of the three conventional prognostic factors only. a Comparison of ROC curves computed with the relapse probability calculated by the BRCA1-related model (solid line) and the three conventional prognostic factor model (dash line). b Patients were classified in two groups: good or bad prognosis, according to the threshold needed to obtain 90 % sensitivity in relapse detection. Comparison of Kaplan-Meier curves computed with the patient group affectation calculated by the two models is represented. c. Classification performances of the two models at threshold fixed to obtain 90 % sensitivity in relapse detection. d. Coefficient and odds ratio of the model including BRCA1 expression parameters