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Table 1 Correlation of plasma miR-449a expression with patients’ clinicopathologic variables in human hepatocellular carcinomas

From: MiR-449a suppresses the epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by multiple targets

Variable

miR-449a

All cases

Low expression

High expression

P value*

Age (years)

   

0.710

 ≤50a

31

14 (45.2 %)

17 (54.8 %)

 

 >50

46

24 (52.2 %)

22 (47.8 %)

 

Sex

   

0.768

 Male

67

34 (50.7 %)

33 (49.3 %)

 

 Female

10

4 (40.0 %)

6 (60.0 %)

 

Etiology

   

0.702

 HBV

67

32 (47.8 %)

35 (52.2 %)

 

 None

10

6 (60.0 %)

4 (40.0 %)

 

AFP (ng/ml)

   

0.052

 ≤20

44

17 (38.6 %)

27 (61.4 %)

 

 >20

33

21 (63.6 %)

12 (36.4 %)

 

Liver cirrhosis

   

0.307

 Yes

55

30 (54.5 %)

25 (45.5 %)

 

 No

22

8 (36.4 %)

14 (63.6 %)

 

Tumor size (cm)

   

0.016

 ≤5

43

16 (37.2 %)

27 (62.8 %)

 

 >5

34

22 (64.7 %)

12 (35.3 %)

 

Tumor multiplicity

   

0.014

 Single

47

18 (38.3 %)

29 (61.7 %)

 

 Multiple

30

20 (66.7 %)

10 (33.3 %)

 

Differentiation

 Well

10

3 (30.0 %)

7 (70.0 %)

0.137

 Moderate

43

25 (58.1 %)

18 (41.9 %)

 

 Poor

20

7 (35.0 %)

13 (65.0 %)

 

 Undifferentiated

4

3 (75.0 %)

1 (25.0 %)

 

Stage

 I

7

1 (14.3.0 %)

6 (85.7 %)

0.001

 II

23

7 (30.4 %)

16 (69.6 %)

 

 III

31

15 (48.4 %)

16 (51.6 %)

 

 IV

16

15 (93.8 %)

1 (6.2 %)

 

Distant metastasis

   

0.014

 M1

9

8 (88.9 %)

1 (11.1 %)

 

 MX

68

30 (44.1 %)

38 (55.9 %)

 
  1. *Chi-square test; aMean age; HBV, hepatitis B virus; AFP indicates alpha-fetoprotein.