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Table 1 Correlation of plasma miR-449a expression with patients’ clinicopathologic variables in human hepatocellular carcinomas

From: MiR-449a suppresses the epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by multiple targets

Variable miR-449a
All cases Low expression High expression P value*
Age (years)     0.710
 ≤50a 31 14 (45.2 %) 17 (54.8 %)  
 >50 46 24 (52.2 %) 22 (47.8 %)  
Sex     0.768
 Male 67 34 (50.7 %) 33 (49.3 %)  
 Female 10 4 (40.0 %) 6 (60.0 %)  
Etiology     0.702
 HBV 67 32 (47.8 %) 35 (52.2 %)  
 None 10 6 (60.0 %) 4 (40.0 %)  
AFP (ng/ml)     0.052
 ≤20 44 17 (38.6 %) 27 (61.4 %)  
 >20 33 21 (63.6 %) 12 (36.4 %)  
Liver cirrhosis     0.307
 Yes 55 30 (54.5 %) 25 (45.5 %)  
 No 22 8 (36.4 %) 14 (63.6 %)  
Tumor size (cm)     0.016
 ≤5 43 16 (37.2 %) 27 (62.8 %)  
 >5 34 22 (64.7 %) 12 (35.3 %)  
Tumor multiplicity     0.014
 Single 47 18 (38.3 %) 29 (61.7 %)  
 Multiple 30 20 (66.7 %) 10 (33.3 %)  
Differentiation
 Well 10 3 (30.0 %) 7 (70.0 %) 0.137
 Moderate 43 25 (58.1 %) 18 (41.9 %)  
 Poor 20 7 (35.0 %) 13 (65.0 %)  
 Undifferentiated 4 3 (75.0 %) 1 (25.0 %)  
Stage
 I 7 1 (14.3.0 %) 6 (85.7 %) 0.001
 II 23 7 (30.4 %) 16 (69.6 %)  
 III 31 15 (48.4 %) 16 (51.6 %)  
 IV 16 15 (93.8 %) 1 (6.2 %)  
Distant metastasis     0.014
 M1 9 8 (88.9 %) 1 (11.1 %)  
 MX 68 30 (44.1 %) 38 (55.9 %)  
  1. *Chi-square test; aMean age; HBV, hepatitis B virus; AFP indicates alpha-fetoprotein.