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Fig. 6 | BMC Cancer

Fig. 6

From: MiR-449a suppresses the epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by multiple targets

Fig. 6

MiR-449a regulates AKT/GSK-3α/GSK-3β/Snail signaling and subcellular location of Snail. a miR-449a inhibited AKT/GSK-3α/GSK-3β/Snail signaling in Huh7 cells. b miR-449a repressed the expression of Snail in LM9 cells. c miR-449a reduced the nuclear accumulation of Snail in LM9 cells. miR-control-Huh7, miR-control-LM9 and miR-449a-Huh7, miR-449a-LM9 cells were analyzed by immunoblotting and immunofluorescent staining. Scale bar, 40 μm. d Expression of snail was compared by western blot analysis nuclear and cytoplasmic extraction of miR-control-Huh7 and miR-449a-Huh7 cells. LaminB was used as a loading control

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