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Fig. 1 | BMC Cancer

Fig. 1

From: MiR-449a suppresses the epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by multiple targets

Fig. 1

The levels of mature miR-449a expression in human HCC cell lines and tissues by real-time PCR. a miR-449a expression was reduced in HCC tissues with the PVTT. The levels of miR-449a in normal livers (n = 18), HCC tissues without the PVTT (n = 66) and with the PVTT (n = 11) were detected by qPCR and were then normalized to the expression of RNU6B to yield the relative miR-449a levels for individual sample. The median level of miR-449a in all HCC tissues was set as cut-off. Mann–Whitney U-test was applied to compare the differences in the miR-449a expression between the indicated cohorts. *P < 0.05, ***P < 0.001. b KaplaneMeier analysis for survival of patients with HCC as a function of miR-449a levels. Probability of patient survival, high-expression of miR-449a, n = 39; low-expression of miR-449a, n = 38 (p < 0.001). c Expression levels of miR-449a were examined by real-time PCR in LO2 cells and six HCC cell lines. Experiments were performed three times. Data are presented as means ± SE (p < 0.0001, independent t test)

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