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Table 3 Disease free survival and ROS1 expression

From: Clinical and pathological significance of ROS1 expression in intrahepatic cholangiocarcinoma

   Univariate Multivariate
   Median(m) p. HR [95 % CI] p.
ROS1 expression Negative vs. positive 9 vs. 30 0.006 0.58 [0.37–0.89] 0.014
Size of tumor Cm 1.053a 0.008 1.06 [1.01–1.11] 0.019
Number of tumor Single vs. multiple 15 vs. 4 0.001 2.27 [1.24–4.16] 0.008
Gross type Mass forming vs. periductal 9 vs. 89 <0.001 0.48 [0.24–0.98] 0.042
Differentiation Well vs. moderate to poor 89 vs. 9 <0.001 2.22 [1.09–4.51] 0.028
Perineural invasion Absent vs. present 19 vs. 9 0.039 1.63 [1.04–2.55] 0.034
Vascular invasion Absent vs present 15 vs. 8 0.051   
Lymphatic invasion Absent vs present 19 vs. 8 0.009   
Histologic type Papillary/mucinous vs. NA vs. 11 0.026   
  Tubular/undifferentiated     
  1. aMean hazard ratio by Cox proportional hazard model; HR, hazard ratio; CI, confidential interval