From: Clinical and pathological significance of ROS1 expression in intrahepatic cholangiocarcinoma
 |  | Univariate | Multivariate | ||
---|---|---|---|---|---|
 |  | Median(m) | p. | HR [95 % CI] | p. |
ROS1 expression | Negative vs. positive | 9 vs. 30 | 0.006 | 0.58 [0.37–0.89] | 0.014 |
Size of tumor | Cm | 1.053a | 0.008 | 1.06 [1.01–1.11] | 0.019 |
Number of tumor | Single vs. multiple | 15 vs. 4 | 0.001 | 2.27 [1.24–4.16] | 0.008 |
Gross type | Mass forming vs. periductal | 9 vs. 89 | <0.001 | 0.48 [0.24–0.98] | 0.042 |
Differentiation | Well vs. moderate to poor | 89 vs. 9 | <0.001 | 2.22 [1.09–4.51] | 0.028 |
Perineural invasion | Absent vs. present | 19 vs. 9 | 0.039 | 1.63 [1.04–2.55] | 0.034 |
Vascular invasion | Absent vs present | 15 vs. 8 | 0.051 | Â | Â |
Lymphatic invasion | Absent vs present | 19 vs. 8 | 0.009 | Â | Â |
Histologic type | Papillary/mucinous vs. | NA vs. 11 | 0.026 | Â | Â |
 | Tubular/undifferentiated |  |  |  |  |