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Table 1 ROS1 expression and clinicopathologic parameters

From: Clinical and pathological significance of ROS1 expression in intrahepatic cholangiocarcinoma

ROS1 expression   N (%) Negative Positive p.
  122 (62.9) 72 (37.1)
Sex (194) Male 149 (76.8) 96 (64.4) 53 (35.6) 0.418
  Female 45 (23.2) 26 (57.8) 19 (42.2)  
Age (yr) (194) 62 [37–89] 60.1 ± 9.0 61.5 ± 10.4 0.347
Size (cm) (185) 5.0 [0.3–26.0] 5.5 ± 2.9 5.6 ± 3.9 0.673
Operation (183) Lobectomy 129 (70.5) 84 (65.1) 45 (34.9) 0.635
  Segmentectomy 54 (29.5) 32 (59.3) 22 (40.7)  
Number (188) Single 169 (89.9) 107 (63.3) 62 (36.7) 0.114
  Multiple 19 (10.1) 14 (73.7) 5 (26.3)  
Gross type (189) Mass forming 133 (70.4) 91 (68.4) 42 (31.6) 0.006*
  Periductal infiltrating 10 (5.3) 5 (50.0) 5 (50.0)  
  Intraductal polypoid 24 (12.7) 8 (33.3) 16 (66.7)  
  Mixed 22 (11.6) 16 (72.7) 6 (27.3)  
Extent of tumor (188) Confined liver 92 (48.9) 50 (54.3) 42 (45.7) 0.005*
  Extrahepatic invasion 96 (51.1) 71 (74.0) 25 (26.0)  
pT stage (190) Tis 1 (0.5) 1 (100) 0 (0.0) 0.226
  T1 86 (45.3) 52 (60.5) 34 (39.5)  
  T2a 39 (20.5) 21 (53.8) 18 (46.2)  
  T2b 12 (6.3) 9 (75.0) 3 (25.0)  
  T3 50 (26.3) 37 (74.0) 13 (26.0)  
  T4 2 (1.1) 1 (50.0) 1 (50.0)  
pN stage (106) pN0 61 (57.5) 35 (57.4) 26 (42.6) 0.462
  pN1 45 (42.5) 29 (64.4) 16 (35.6)  
Resection margin (177) R0 151 (85.3) 100 (66.2) 51 (33.8) 0.400
  R1-2 26 (14.7) 15 (57.7) 11 (42.3)  
Lymphatic invasion (187) Absent 117 (62.6) 71 (60.7) 46 (39.3) 0.278
  Present 70 (37.4) 48 (68.6) 22 (31.4)  
Vascular invasion (180) Absent 127 (70.6) 81 (63.8) 46 (36.2) 0.595
  Present 53 (29.4) 36 (67.9) 17 (32.1)  
Neural invasion (184) Absent 137 (74.5) 89 (65.0) 48 (35.0) 0.687
  Present 47 (25.5) 29 (61.7) 18 (38.3)  
Differentiation (194) Well 34 (17.5) 14 (41.2) 20 (58.8) 0.150
  Moderate 112 (57.7) 75 (67.0) 37 (33.0)  
  Poor 48 (24.7) 33 (68.8) 15 (31.3)  
Histologic subtype (194) Adenocarcinoma, tubular 167 (86.1) 111 (66.5) 56 (33.5) 0.009*
  Papillary or mucinous carcinoma 15 (7.7) 4 (26.7) 11 (73.3)  
  Othersa 12 (6.2) 7 (58.3) 5 (41.7)  
Cell type (172) Nonintestinal type 137 (79.7) 92 (67.2) 45 (32.8) 0.019*
  Intestinal type 35 (20.3) 19 (54.3) 19 (54.3)  
Progression (194) No evidence of disease 62 (32.0) 34 (54.8) 28 (45.2) 0.024*
  Recurrence or metastasis 119 (61.3) 83 (69.7) 36 (30.3)  
  Censored 13 (6.7) 5 (38.5) 8 (61.5)  
Death (194) Alive 60 (30.9) 32 (53.3) 28 (46.7) 0.176
  Deceased 126 (64.9) 85 (67.5) 41 (32.5)  
  Censored 8 (4.1) 5 (62.5) 3 (37.5)  
  1. Median [range]; mean ± sd
  2. *p < 0.05
  3. aUndifferentiated carcinoma, adenosquamous carcinoma, mixed adenocarcinoma and neuroendocrine carcinoma