Skip to main content

Advertisement

Table 2 Univariate analysis of predictive factors for DNM

From: Expression of Oct3/4 and Nanog in the head and neck squamous carcinoma cells and its clinical implications for delayed neck metastasis in stage I/II oral tongue squamous cell carcinoma

Variable   n DNM− (n = 37) DNM+ (n = 13) P value
Clinicopathological factors       
Age >60 21 17 (80.9 %) 4 (19.1 %) 0.267
  60 29 20 (69.0 %) 9 (31.0 %)  
T classification T1 34 28 (82.4 %) 6 (17.6 %) 0.055
  T2 16 9 (56.2 %) 7 (43.8 %)  
Differentiation Well 42 32 (76.2 %) 10 (23.8 %) 0.891
  Moderate, Poor 8 5 (62.5 %) 3 (37.5 %)  
Depth of invasion <4 mm 35 28 (80.0 %) 7 (20.0 %) 0.963
  4 mm 15 9 (60.0 %) 6 (40.0 %)  
Mode of invasion Grade 1, 2 24 21 (87.5 %) 3 (12.5 %) 0.036*
  Grade 3, 4 26 16 (61.5 %) 10 (38.5 %)  
Nest shape A 26 21 (80.8 %) 5 (19.2 %) 0.208
  B 24 16 (66.7 %) 8 (33.3 %)  
Vascular invasion Negative 43 35 (81.4 %) 8 (18.6 %) 0.009*
  Positive 7 2 (28.6 %) 5 (71.4 %)  
Lymphatic invasion Negative 44 32 (72.7 %) 12 (27.3 %) 0.502
  Positive 6 5 (83.4 %) 1 (16.6 %)  
Perineural invasion Negative 48 36 (75.0 %) 12 (25.0 %) 0.456
  Positive 2 1 (50.0 %) 1 (50.0 %)  
Muscular invasion Negative 23 21 (91.3 %) 2 (8.7 %) 0.010*
  Positive 27 16 (59.3 %) 11 (40.7 %)  
Immunohistochemical markers       
Oct3/4 Negative 38 33 (86.8 %) 5 (13.2 %) 0.001*
  Positive 12 4 (33.3 %) 8 (66.7 %)  
Nanog Negative 40 34 (85.0 %) 6 (15.0 %) 0.001*
  Positive 10 3 (30.0 %) 7 (70.0 %)  
  1. *Statistically significant according to Fisher’s exact test