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Table 2 Univariate analysis of predictive factors for DNM

From: Expression of Oct3/4 and Nanog in the head and neck squamous carcinoma cells and its clinical implications for delayed neck metastasis in stage I/II oral tongue squamous cell carcinoma

Variable

 

n

DNM− (n = 37)

DNM+ (n = 13)

P value

Clinicopathological factors

      

Age

>60

21

17

(80.9 %)

4

(19.1 %)

0.267

 

≦60

29

20

(69.0 %)

9

(31.0 %)

 

T classification

T1

34

28

(82.4 %)

6

(17.6 %)

0.055

 

T2

16

9

(56.2 %)

7

(43.8 %)

 

Differentiation

Well

42

32

(76.2 %)

10

(23.8 %)

0.891

 

Moderate, Poor

8

5

(62.5 %)

3

(37.5 %)

 

Depth of invasion

<4 mm

35

28

(80.0 %)

7

(20.0 %)

0.963

 

≧4 mm

15

9

(60.0 %)

6

(40.0 %)

 

Mode of invasion

Grade 1, 2

24

21

(87.5 %)

3

(12.5 %)

0.036*

 

Grade 3, 4

26

16

(61.5 %)

10

(38.5 %)

 

Nest shape

A

26

21

(80.8 %)

5

(19.2 %)

0.208

 

B

24

16

(66.7 %)

8

(33.3 %)

 

Vascular invasion

Negative

43

35

(81.4 %)

8

(18.6 %)

0.009*

 

Positive

7

2

(28.6 %)

5

(71.4 %)

 

Lymphatic invasion

Negative

44

32

(72.7 %)

12

(27.3 %)

0.502

 

Positive

6

5

(83.4 %)

1

(16.6 %)

 

Perineural invasion

Negative

48

36

(75.0 %)

12

(25.0 %)

0.456

 

Positive

2

1

(50.0 %)

1

(50.0 %)

 

Muscular invasion

Negative

23

21

(91.3 %)

2

(8.7 %)

0.010*

 

Positive

27

16

(59.3 %)

11

(40.7 %)

 

Immunohistochemical markers

      

Oct3/4

Negative

38

33

(86.8 %)

5

(13.2 %)

0.001*

 

Positive

12

4

(33.3 %)

8

(66.7 %)

 

Nanog

Negative

40

34

(85.0 %)

6

(15.0 %)

0.001*

 

Positive

10

3

(30.0 %)

7

(70.0 %)

 
  1. *Statistically significant according to Fisher’s exact test