Fig. 7
From: The Aplidin analogs PM01215 and PM02781 inhibit angiogenesis in vitro and in vivo
Aplidin analogs inhibit physiological and VEGF-induced angiogenesis in the chicken chorioallantoic membrane (CAM) in vivo. a Antiangiogenic effects of Aplidin derivatives were tested in vivo in CAM after repeated (2 x) topical application of 1 nmol of the drugs to Permanox™ rings with or without recombinant human VEGF165 (1 μg/ring). Representative CAM areas of chicken embryos were treated with Aplidin analogs and in combination with VEGF. b Statistical analysis for each compound (n = 6 animals). Aplidin analogs inhibited VEGF-induced angiogenesis (**, p < 0.05, comparison to human VEGF165 + PBS) and physiological neovascularization (*, p < 0.05, comparison to PBS treatment)