Fig. 1
From: The Aplidin analogs PM01215 and PM02781 inhibit angiogenesis in vitro and in vivo
Chemical structure of Aplidin™ and the two novel Aplidin derivatives with modified side-chains (boxes). PM01215 and PM02781 are analogs of Aplidin™, in which the pyruvyl-proline side-chain was replaced with a urea derivative based on phenylisocyanate. Additionally, in PM02781 the α − (α − hydroxyisovaleryl) propionyl (Hip) group that is present in the depsipeptide cycle and connected to an isostatine unit by an ester bond was replaced with L-valine. Note: Both analogs are easier to synthesize than Aplidin™