Drugs and No. prescriptions | Cases (%) (n = 70) | Controls (%) (n = 419) | Crude OR (95 % CI) | Adjusted OR (95 % CI) model 1a | Adjusted OR (95 % CI) model 2b |
---|---|---|---|---|---|
Metformin | |||||
 No prior use | 23 (32.9) | 165 (39.4) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) |
 Any use | 47 (67.1) | 254 (60.6) | 1.40 (0.78–2.49) | 1.30 (0.68–2.47) | 1.42 (0.74–2.73) |
 1–29 | 21 (30.0) | 129 (30.8) | 1.21 (0.61–2.39) | 1.18 (0.57–2.45) | 1.28 (0.61–2.67) |
 ≥30 | 26 (37.1) | 125 (29.8) | 1.60 (0.83–3.09) | 1.48 (0.69–3.18) | 1.67 (0.76–3.67) |
Sulfonylurea | |||||
 No prior use | 32 (45.7) | 231 (55.1) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) |
 Any use | 38 (54.3) | 188 (44.9) | 1.48 (0.88–2.48) | 1.51 (0.83–2.75) | 1.46 (0.78–2.72) |
 1–29 | 19 (27.1) | 97 (23.2) | 1.43 (0.76–2.67) | 1.56 (0.79–3.10) | 1.52 (0.76–3.07) |
 ≥30 | 19 (27.1) | 91 (21.7) | 1.53 (0.81–2.89) | 1.41 (0.68–2.94) | 1.35 (0.62–2.90) |
Insulin | |||||
 No prior use | 52 (74.3) | 349 (83.3) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) |
 Any use | 18 (25.7) | 70 (16.7) | 1.83 (0.98–3.42) | 1.94 (0.97–3.88) | 1.84 (0.90–3.76) |
TZD | |||||
 No prior use | 61 (87.1) | 366 (87.4) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) |
 Any use | 9 (12.9) | 53 (12.7) | 1.03 (0.45–2.33) | 0.80 (0.33–1.92) | 0.66 (0.26–2.90) |