Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer

Table 1 Clinical details of patients treated with surgical resection of gastroesophageal cancers

Variable	Score	Neo-adjuvant Chemotherapy	No Neo-adjuvant Chemotherapy	P value*
Age	>Median	9	15	0.073
Age	< Median	27	16	0.073
Histology	Adenocarcinoma	31	24	0.180
Histology	Squamous	5	7	0.180
Stage	I	11	3	0.109
	II	10	12
	III	15	16
Site	Oesophagus	30	25	0.755
	(includes Siewert Type I and II junctional)
		6	6
	Gastric
	(includes Siewert Type III junctional)
Circumferential Resection Margins	Positive	6	11	0.378
Circumferential Resection Margins	Negative	30	20	0.378

There was no significant difference in clinic-pathological characteristics between patients who did and did not receive neo-adjuvant chemotherapy prior to surgery. SPHK1 immunohistochemistry was performed on this cohort as described. *χ² test. Two-sided p value