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Fig. 6 | BMC Cancer

Fig. 6

From: Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer

Fig. 6

Synergistic effects of cisplatin and safingol in gastroesophageal cancer cell lines. a AGSCIS5 cisplatin resistant gastric cancer cell line and b N87 gastric cancer cell line. Cisplatin: Safingol ratio is constant in the combination experiments, and each data point has 6 replicates. Mean growth from three independent experiments shown, relative cell survival ((MTT OD value for cells treated as indicated /MTT OD value for untreated control)*100, ±SEM). Tables show combination index for cisplatin and safingol at different ICs for each cell line and show synergy between the treatments across different doses

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