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Fig. 1 | BMC Cancer

Fig. 1

From: The regulatory and predictive functions of miR-17 and miR-92 families on cisplatin resistance of non-small cell lung cancer

Fig. 1

Both the miR-17 and miR-92 families were down-regulated in cisplatin resistance cells (a) Schematic representation of the four families of the miR-17 ~ 92 cluster and paralogous. miRNAs sharing the same seed sequence and involving in the same family were represented by boxes of the same pattern. b Down-regulation of miR-17 and miR-92 families in microarray experiments was validated by RT-PCR analysis. c Over-expression of different miRNA of miR-17 and miR-92 families decreased cisplatin resistance of A549/DDP cells significantly. d Apoptosis assays induced by cisplatin (2 μg/ml) were observed in different miRNA mimics treated A549/DDP cells. (n = 3, *P < 0.05)

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