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Table 2 Body weight change and baseline characteristics

From: Prognostic influence of body mass index and body weight gain during adjuvant FOLFOX chemotherapy in Korean colorectal cancer patients

 

Total

> 5 kg loss

2.1–5 kg loss

± 2 kg

2–4.9 kg gain

≥ 5 kg gain

p-value*

  

N (%)

N (%)

N (%)

N (%)

N (%)

 

Total

522

16 (3.1)

80 (15.3)

196 (37.5)

136 (26.1)

94 (18.0)

 

Baseline BMIa

 Normal or underweight

184

2 (1.1)

16 (8.7)

63 (34.2)

46 (25.0)

57 (31.0)

< 0.001

 Overweight

152

3 (2.0)

23 (15.1)

58 (38.2)

45 (29.6)

23 (15.1)

< 0.001

 Obese

186

11 (5.9)

41 (22.0)

75 (40.3)

45 (24.2)

14 (7.5)

 

Age

  < 65 years

366

11 (3.0)

52 (14.2)

128 (35.0)

97 (26.5)

78 (21.3)

0.006

  ≥ 65 years

156

5 (3.2)

28 (17.9)

68 (43.6)

39 (25.0)

16 (10.3)

0.003

Sex

 Male

312

11 (3.5)

57 (18.3)

115 (36.9)

71 (22.8)

58 (18.6)

0.11

 Female

210

5 (2.4)

23 (11.0)

81 (38.6)

65 (31.0)

36 (17.1)

0.67

Location

 Proximal

181

3 (1.7)

30 (16.6)

66 (36.5)

45 (24.9)

37 (20.4)

0.40

 Distal

341

13 (3.8)

50 (14.7)

130 (38.1)

91 (26.7)

57 (16.7)

0.29

T stage

 T1 - 3

446

16 (3.6)

67 (15.0)

175 (39.2)

112 (25.1)

76 (17.0)

0.056

 T4

76

0 (0.0)

13 (17.1)

21 (27.6)

24 (31.6)

18 (23.7)

0.16

N stage

 N0 - 1

380

10 (2.9)

61 (16.1)

142 (37.4)

105 (27.6)

62 (16.3)

0.55

 N2

142

6 (4.2)

19 (13.4)

54 (38.0)

31 (21.8)

32 (22.5)

0.10

Tumor stage

 II, high-risk

78

2 (2.6)

9 (11.5)

24 (30.8)

29 (37.2)

14 (17.9)

0.15

 III

444

14 (3.2)

71 (16.0)

172 (38.7)

107 (24.1)

80 (18.0)

1.00

Histology

 MAC

27

1 (3.7)

5 (18.5)

6 (22.2)

5 (18.5)

10 (37.0)

0.180

 Non-MAC

495

15 (3.0)

75 (15.2)

190 (38.4)

131 (26.5)

84 (17.0)

0.017**

Microsatellite status (N = 517)

 MSS + MSI-L

480

14 (2.9)

73 (15.2)

186 (38.8)

124 (25.8)

83 (17.3)

0.33

 MSI-H

37

1 (2.7)

7 (18.9)

9 (24.3)

10 (27.0)

10 (27.0)

0.14

  1. Abbreviations: MAC mucinous adenocarcinoma, MSS microsatellite stable, MSI-L microsatellite instability-low, MSI-H microsatellite instability-high
  2. *Upper row: linear-by-linear association test, lower row: Χ2 test of ≥ 5 kg gain group vs. the others
  3. **Fisher’s exact test of ≥ 5 kg gain group vs. the others
  4. aNormal or underweight, ≤ 22.9 kg/m2; overweight, 23–24.9 kg/m2; and obese, BMI ≥ 25 kg/m2