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Table 3 Genomic comparison between NAC-responders and non-responders. Enriched KEGG pathways in non-responders with shrinkage rates 50 %

From: Genomic profile predicts the efficacy of neoadjuvant chemotherapy for cervical cancer patients

KEGG pathway Number of genes NES p-value q-value
Metabolism-related
 METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 34 2.021684 <0.01 <0.001
 DRUG_METABOLISM_CYTOCHROME_P450 36 1.987058 <0.01 0.002063
 PROPANOATE_METABOLISM 29 1.925244 <0.01 0.001375
 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION 41 1.920898 <0.01 0.001179
 BUTANOATE_METABOLISM 26 1.873636 <0.01 0.003011
 GLUTATHIONE_METABOLISM 42 1.652794 <0.01 0.031592
DNA repair system-related
 MISMATCH_REPAIR 21 1.935372 <0.01 0.00165
 HOMOLOGOUS_RECOMBINATION 23 1.754282 <0.01 0.009237
 BASE_EXCISION_REPAIR 33 1.62332 <0.01 0.041855
 NUCLEOTIDE_EXCISION_REPAIR 42 1.588174 <0.01 0.042931
Others
 DNA_REPLICATION 33 2.245259 <0.01 <0.001
 CELL_CYCLE 107 2.148499 <0.01 <0.001
 ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 25 1.668492 0.019608 0.027948
 GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR 23 1.597785 0.017544 0.042713
  1. KEGG Kyoto Encyclopedia of Genes and Genomes Database, NES Normalized Enrichment Score