Table 3 Genomic comparison between NAC-responders and non-responders. Enriched KEGG pathways in non-responders with shrinkage rates ≦ 50 %

 METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450

34

2.021684

<0.01

<0.001

 DRUG_METABOLISM_CYTOCHROME_P450

36

1.987058

<0.01

0.002063

 PROPANOATE_METABOLISM

29

1.925244

<0.01

0.001375

 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION

41

1.920898

<0.01

0.001179

 BUTANOATE_METABOLISM

26

1.873636

<0.01

0.003011

 GLUTATHIONE_METABOLISM

42

1.652794

<0.01

0.031592

 MISMATCH_REPAIR

21

1.935372

<0.01

0.00165

 HOMOLOGOUS_RECOMBINATION

23

1.754282

<0.01

0.009237

 BASE_EXCISION_REPAIR

33

1.62332

<0.01

0.041855

 NUCLEOTIDE_EXCISION_REPAIR

42

1.588174

<0.01

0.042931

 DNA_REPLICATION

33

2.245259

<0.01

<0.001

 CELL_CYCLE

107

2.148499

<0.01

<0.001

 ALDOSTERONE_REGULATED_SODIUM_REABSORPTION

25

1.668492

0.019608

0.027948

 GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR

23

1.597785

0.017544

0.042713