Fig. 3

Genomic analysis of cervical cancer cell lines. a Left: Correlation analysis of GMP scores with intracellular GSH concentrations within 4 cervical cancer cell lines (n = 5). GMP scores were correlated with the total GSH concentration (r = 0.72). Right: Apoptosis was induced in each cell line in the presence of several concentrations of CPT-11 (0, 10, or 100 μM). *: p < 0.05. n.s.: not significant. b Targeted sequencing of the UGT1A1 gene in SKGIIIa. UGT1A1*28 polymorphism is designated as two base pair insertions of TA in the TATA box within the promoter region of the UGT1A1 gene. The A(TA)6TAA sequence in the wild-type allele become A(TA)7TAA in UGT1A1*28 polymorphism. Heterozygous UGT1A1*28 polymorphism exhibited waveform distortion downstream of the promoter region of the gene