Fig. 2
From: Critical role of CDK11p58 in human breast cancer growth and angiogenesis
CDK11p58 inhibits the angiogenesis of breast cancer. (a) Association of CDK11p58 expression and VEGF expression in breast cancer in nude mice. Immunohistochemical staining for the expression of CDK11, VEGF, CD31, CD34 in human breast cancer tissues. (b) Representative pictures of pseudocapillary formation in matrigel from HUVECs in 0.1 % FBS exposed to breast cancer cell culture at 12 h after cell seeding. (c) Quantification of pseudocapillaries obtained by counting numbers of complete circles/wells. Numbers represent the mean of 6 samples ± SEM of three experiments run in triplicate. (d) CDK11p58 inhibits the vascularization of MDA-MB231 xenograft tumors in mice. The images were reconstructed using the filtered back projection (FBP) algorithm. (e) Quantitative analysis of angiogenesis of MDA-MB231 xenograft tumors in implants. For each condition (n = 6), the means of 6 samples ± SD are shown. **P < 0.01, CDK11p58 group compared to the pBABE group