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Fig. 3 | BMC Cancer

Fig. 3

From: Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent γ-H2AX and telomerase regulation in triple-negative breast cancer

Fig. 3

Combinatorial resveratrol and pterostilbene induces apoptosis in breast cancer cells. a HCC1806 cells undergo tremendous apoptosis after 72 h of treatment with resveratrol at 15 μM and combinational treatments at 15 μM resveratrol and 5 μM pterostilbene. Percent apoptosis in combinatorial treatment in HCC1806 cells was significantly elevated in comparison to DMSO (vehicle control) and individual treatments. b MDA-MB-157 cells underwent apoptosis with 5 μM pterostilbene and combinational treatment by 72 h. Both of the cell types were found to be highly significant in change in percent apoptosis in comparison to DMSO (vehicle control). c MCF10A cells did not show any significant change in apoptosis after 72 h of treatment with any of the tested compounds. Values are representative of three independent experiments and are shown as percent of control ± SE; *P <0.05, **P <0.01

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BMC Cancer

ISSN: 1471-2407

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