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Table 2 Characterization of CpG islands (CGIs) of significantly deregulated ABC transporter genes. CGI locations are provided relative to transcription start site (TSS). Gene expression changes were identified in comparisons: Gleason score 7 versus 6 (G7/6); tumor stage 3 versus 2 (pT3/2); prostate cancer versus noncancerous prostate tissue (PCa/NPT); TMPRSS2-ERG fusion transcript negative versus positive cases (F−/+)

From: Frequent down-regulation of ABC transporter genes in prostate cancer

Gene name Gene expression Group comparison Gene location CGI presence GC content, % CGI length, bp CGI location according to TSS
ABCA2 Up G7/6 9q34 Yes 78 1196 +134/+1329
ABCA4 Up G7/6 1p22 No  –  –  –
ABCA5 Down pT3/2 17q24.3 Yes 67 1319 −669/+650
ABCA6 Down pT3/2 17q24.3 No
ABCA8 Down PCa/NPT; F−/+ 17q24 No
ABCA10 Down pT3/2 17q24 No
ABCA11 Down BCR+/−; pT3/2 4p16.3 Yes 63 724 −10/+714
ABCA13 Down pT3/2; F−/+ 7p12.3 Yesa 62 618 +283291/+283908
ABCB1 Down PCa/NPT; F−/+; pT3/2 7q21.12 Yes 57 1048 +112174/+113221
ABCC4 Up PCa/NPT 13q32 Yes 68 1355 −849/+506
ABCC6 Down PCa/NPT 16p13.1 Yesa 58 1397 −1022/+375
ABCC9 Down PCa/NPT; F−/+ 12p12.1 Yes 56 1019 −733/+286
ABCC10 Down PCa/NPT 6p21.1 Yes 59 964 −454/+510
ABCD2 Down PCa/NPT 12q12 No
ABCF1 Down F−/+ 6p21.33 Yes 58 1222 −655/+567
ABCF3 Up G7/6 3q27.1 Yes 62 737 −269/+468
ABCG1 Up PCa/NPT 21q22.3 Yes 67 1709 −437/+1272
ABCG2 Down PCa/NPT 4q22 Yes 65 1053 −589/+464
ABCG4 Down PCa/NPT 11q23.3 Yes 73 888 −262/+626
  1. aPredicted CGI