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Table 1 Characteristics of study group. ABCB1 analysis group was involved in the ABCB1 gene expression and methylation analysis, while TLDA analysis group was profiled for the ABC transporter genes expression. NPT – noncancerous prostate tissue; PCa – prostate cancer; BCR – biochemical recurrence; PSA – prostate-specific antigen

From: Frequent down-regulation of ABC transporter genes in prostate cancer

Variable ABCB1 analysis group TLDA analysis group
N = 93 N = 16
NPT PCa NPT PCa
N = 15 + 10a N = 78 N = 6 N = 10
Mean age in years ± SEM 62.13 ± 1.01 60.76 ± 0.85 61.33 ± 1.09 62.9 ± 2.04
Pathological stage     
 pT2   52   5
 pT3   25   5
Gleason score     
 6   18   3
  ≥ 7   54   7
 Unknown   1   
BCR     
 Yes   20   5
 No   53   5
 Unknown   5   
TMPRSS2-ERG status     
 Positive   51   6
 Negative   27   4
Mean PSA level at diagnosis, ng/ml ± SEM   10.57 ± 1.25   11.07 ± 3.03
Methylation status of ABCB1 promoter     
 Methylated 4 56   5
 Unmethylated 15 22   5
 Unknown 6   6  
Mean expression of ABCB1, ∆Cq ± SEM 7.50 ± 0.24 8.14 ± 0.13 5.01 ± 0.18 5.61 ± 0.17
  1. aTen additional samples were included in ABCB1 methylation analysis