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Table 2 Gene expression data of biopsies and laser microdissected (LCM) colon epithelial cells

From: DNA hypermethylation and decreased mRNA expression of MAL, PRIMA1, PTGDR and SFRP1 in colorectal adenoma and cancer

 

Normal

Adenoma

CRC

P-value (N vs. Ad)

P-value (N vs. CRC)

P-value (Ad vs. CRC)

Mean normalised intensity values ± SD

Mean normalised intensity values ± SD

Mean normalised intensity values ± SD

Biopsy samples

203180_at (ALDH1A3)

6.36 ± 0.92

6.53 ± 0.86

7.29 ± 1.45

0.34

p < 0.01

p < 0.01

203685_at (BCL2)

8.90 ± 0.52

7.96 ± 1.08

6.98 ± 1.22

p < 0.01

p < 0.01

p < 0.01

206430_at (CDX1)

11.70 ± 0.28

11.17 ± 0.35

10.84 ± 0.73

p < 0.01

p < 0.01

p < 0.01

202404_s_at (COL1A2)

9.75 ± 0.78

10.25 ± 1.11

12.31 ± 1.67

0.01

p < 0.01

p < 0.01

205676_at (CYP27B1)

2.55 ± 0.10

2.88 ± 0.54

3.15 ± 0.95

p < 0.01

p < 0.01

0.09

1554094_at (ENTPD5)

6.41 ± 0.70

4.56 ± 0.79

4.15 ± 1.29

p < 0.01

p < 0.01

0.06

208963_x_at (FADS1)

4.82 ± 0.70

5.05 ± 1.14

6.36 ± 1.65

0.22

p < 0.01

p < 0.01

204777_s_at (MAL)

6.02 ± 0.62

4.86 ± 0.37

4.88 ± 0.59

p < 0.01

p < 0.01

0.86

230087_at (PRIMA1)

4.09 ± 0.97

2.20 ± 0.61

2.31 ± 0.83

p < 0.01

p < 0.01

0.47

234165_at (PTGDR)

5.84 ± 1.08

3.91 ± 1.75

2.81 ± 0.85

p < 0.01

p < 0.01

p < 0.01

204748_at (PTGS2)

4.96 ± 1.33

6.84 ± 2.50

9.88 ± 2.74

p < 0.01

p < 0.01

p < 0.01

202036_s_at (SFRP1)

4.05 ± 1.47

2.18 ± 0.62

2.51 ± 1.28

p < 0.01

p < 0.01

0.11

223121_s_at (SFRP2)

2.87 ± 0.11

2.92 ± 0.28

3.94 ± 1.74

0.29

p < 0.01

p < 0.01

227697_at (SOCS3)

6.10 ± 1.11

7.42 ± 1.65

9.81 ± 2.06

p < 0.01

p < 0.01

p < 0.01

212353_at (SULF1)

6.29 ± 1.04

7.12 ± 1.16

9.23 ± 2.15

p < 0.01

p < 0.01

p < 0.01

215299_x_at (SULT1A1)

11.94 ± 0.53

10.40 ± 0.85

10.34 ± 0.95

p < 0.01

p < 0.01

0.72

203083_at (THBS2)

2.61 ± 0.44

3.46 ± 1.54

7.67 ± 3.13

p < 0.01

p < 0.01

p < 0.01

201666_at (TIMP1)

10.29 ± 0.75

12.20 ± 0.69

12.80 ± 1.04

p < 0.01

p < 0.01

p < 0.01

LCM - colon epithelial cells

203180_at (ALDH1A3)

3.44 ± 0.83

3.35 ± 0.34

3.61 ± 0.73

0.80

0.72

0.45

203685_at (BCL2)

7.02 ± 0.64

6.94 ± 1.56

4.52 ± 2.00

0.91

p < 0.05

p < 0.05

206430_at (CDX1)

10.35 ± 0.57

9.51 ± 0.47

9.38 ± 0.53

p < 0.05

p < 0.05

0.65

202404_s_at (COL1A2)

4.27 ± 1.50

3.28 ± 0.69

7.55 ± 1.02

0.18

p < 0.01

p < 0.01

205676_at (CYP27B1)

2.75 ± 0.04

2.79 ± 0.05

3.07 ± 0.24

0.10

p < 0.01

p < 0.05

1554094_at (ENTPD5)

4.51 ± 0.68

3.80 ± 0.69

2.51 ± 0.08

0.10

p < 0.01

p < 0.01

208963_x_at (FADS1)

3.24 ± 0.21

3.18 ± 0.17

4.44 ± 1.49

0.57

0.08

0.07

204777_s_at (MAL)

2.38 ± 0.17

2.30 ± 0.00

2.31 ± 0.02

0.29

0.34

0.30

230087_at (PRIMA1)

2.63 ± 0.29

3.88 ± 1.08

2.43 ± 0.12

p < 0.05

0.14

p < 0.01

234165_at (PTGDR)

4.71 ± 0.73

3.77 ± 1.02

2.39 ± 0.09

0.10

p < 0.01

p < 0.01

204748_at (PTGS2)

2.61 ± 0.15

2.68 ± 0.24

2.51 ± 0.04

0.59

0.14

0.13

202036_s_at (SFRP1)

2.71 ± 0.35

2.76 ± 0.33

2.54 ± 0.00

0.80

0.27

0.13

223121_s_at (SFRP2)

2.35 ± 0.09

2.36 ± 0.16

2.30 ± 0.00

0.81

0.28

0.34

227697_at (SOCS3)

4.97 ± 1.91

2.82 ± 0.43

4.33 ± 1.69

p < 0.05

0.55

0.06

212353_at (SULF1)

3.08 ± 0.81

2.73 ± 0.09

3.99 ± 1.44

0.32

0.21

0.06

215299_x_at (SULT1A1)

9.35 ± 0.31

8.57 ± 1.16

7.20 ± 0.95

0.14

p < 0.01

p < 0.05

203083_at (THBS2)

2.58 ± 0.14

2.53 ± 0.00

3.54 ± 1.43

0.48

0.13

0.12

201666_at (TIMP1)

4.11 ± 1.06

6.54 ± 1.62

7.85 ± 0.57

p < 0.05

p < 0.01

0.09