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Table 2 Gene expression data of biopsies and laser microdissected (LCM) colon epithelial cells

From: DNA hypermethylation and decreased mRNA expression of MAL, PRIMA1, PTGDR and SFRP1 in colorectal adenoma and cancer

  Normal Adenoma CRC P-value (N vs. Ad) P-value (N vs. CRC) P-value (Ad vs. CRC)
Mean normalised intensity values ± SD Mean normalised intensity values ± SD Mean normalised intensity values ± SD
Biopsy samples
203180_at (ALDH1A3) 6.36 ± 0.92 6.53 ± 0.86 7.29 ± 1.45 0.34 p < 0.01 p < 0.01
203685_at (BCL2) 8.90 ± 0.52 7.96 ± 1.08 6.98 ± 1.22 p < 0.01 p < 0.01 p < 0.01
206430_at (CDX1) 11.70 ± 0.28 11.17 ± 0.35 10.84 ± 0.73 p < 0.01 p < 0.01 p < 0.01
202404_s_at (COL1A2) 9.75 ± 0.78 10.25 ± 1.11 12.31 ± 1.67 0.01 p < 0.01 p < 0.01
205676_at (CYP27B1) 2.55 ± 0.10 2.88 ± 0.54 3.15 ± 0.95 p < 0.01 p < 0.01 0.09
1554094_at (ENTPD5) 6.41 ± 0.70 4.56 ± 0.79 4.15 ± 1.29 p < 0.01 p < 0.01 0.06
208963_x_at (FADS1) 4.82 ± 0.70 5.05 ± 1.14 6.36 ± 1.65 0.22 p < 0.01 p < 0.01
204777_s_at (MAL) 6.02 ± 0.62 4.86 ± 0.37 4.88 ± 0.59 p < 0.01 p < 0.01 0.86
230087_at (PRIMA1) 4.09 ± 0.97 2.20 ± 0.61 2.31 ± 0.83 p < 0.01 p < 0.01 0.47
234165_at (PTGDR) 5.84 ± 1.08 3.91 ± 1.75 2.81 ± 0.85 p < 0.01 p < 0.01 p < 0.01
204748_at (PTGS2) 4.96 ± 1.33 6.84 ± 2.50 9.88 ± 2.74 p < 0.01 p < 0.01 p < 0.01
202036_s_at (SFRP1) 4.05 ± 1.47 2.18 ± 0.62 2.51 ± 1.28 p < 0.01 p < 0.01 0.11
223121_s_at (SFRP2) 2.87 ± 0.11 2.92 ± 0.28 3.94 ± 1.74 0.29 p < 0.01 p < 0.01
227697_at (SOCS3) 6.10 ± 1.11 7.42 ± 1.65 9.81 ± 2.06 p < 0.01 p < 0.01 p < 0.01
212353_at (SULF1) 6.29 ± 1.04 7.12 ± 1.16 9.23 ± 2.15 p < 0.01 p < 0.01 p < 0.01
215299_x_at (SULT1A1) 11.94 ± 0.53 10.40 ± 0.85 10.34 ± 0.95 p < 0.01 p < 0.01 0.72
203083_at (THBS2) 2.61 ± 0.44 3.46 ± 1.54 7.67 ± 3.13 p < 0.01 p < 0.01 p < 0.01
201666_at (TIMP1) 10.29 ± 0.75 12.20 ± 0.69 12.80 ± 1.04 p < 0.01 p < 0.01 p < 0.01
LCM - colon epithelial cells
203180_at (ALDH1A3) 3.44 ± 0.83 3.35 ± 0.34 3.61 ± 0.73 0.80 0.72 0.45
203685_at (BCL2) 7.02 ± 0.64 6.94 ± 1.56 4.52 ± 2.00 0.91 p < 0.05 p < 0.05
206430_at (CDX1) 10.35 ± 0.57 9.51 ± 0.47 9.38 ± 0.53 p < 0.05 p < 0.05 0.65
202404_s_at (COL1A2) 4.27 ± 1.50 3.28 ± 0.69 7.55 ± 1.02 0.18 p < 0.01 p < 0.01
205676_at (CYP27B1) 2.75 ± 0.04 2.79 ± 0.05 3.07 ± 0.24 0.10 p < 0.01 p < 0.05
1554094_at (ENTPD5) 4.51 ± 0.68 3.80 ± 0.69 2.51 ± 0.08 0.10 p < 0.01 p < 0.01
208963_x_at (FADS1) 3.24 ± 0.21 3.18 ± 0.17 4.44 ± 1.49 0.57 0.08 0.07
204777_s_at (MAL) 2.38 ± 0.17 2.30 ± 0.00 2.31 ± 0.02 0.29 0.34 0.30
230087_at (PRIMA1) 2.63 ± 0.29 3.88 ± 1.08 2.43 ± 0.12 p < 0.05 0.14 p < 0.01
234165_at (PTGDR) 4.71 ± 0.73 3.77 ± 1.02 2.39 ± 0.09 0.10 p < 0.01 p < 0.01
204748_at (PTGS2) 2.61 ± 0.15 2.68 ± 0.24 2.51 ± 0.04 0.59 0.14 0.13
202036_s_at (SFRP1) 2.71 ± 0.35 2.76 ± 0.33 2.54 ± 0.00 0.80 0.27 0.13
223121_s_at (SFRP2) 2.35 ± 0.09 2.36 ± 0.16 2.30 ± 0.00 0.81 0.28 0.34
227697_at (SOCS3) 4.97 ± 1.91 2.82 ± 0.43 4.33 ± 1.69 p < 0.05 0.55 0.06
212353_at (SULF1) 3.08 ± 0.81 2.73 ± 0.09 3.99 ± 1.44 0.32 0.21 0.06
215299_x_at (SULT1A1) 9.35 ± 0.31 8.57 ± 1.16 7.20 ± 0.95 0.14 p < 0.01 p < 0.05
203083_at (THBS2) 2.58 ± 0.14 2.53 ± 0.00 3.54 ± 1.43 0.48 0.13 0.12
201666_at (TIMP1) 4.11 ± 1.06 6.54 ± 1.62 7.85 ± 0.57 p < 0.05 p < 0.01 0.09