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Table 3 The association of vitamin D and calcium supplementation with survival from selected cancers in women: sensitivity analysis

From: The effect of pre-diagnostic vitamin D supplementation on cancer survival in women: a cohort study within the UK Clinical Practice Research Datalink

 

Deaths

Cases

Person-

Basic model

Adjusted model

   

Years

HR

95 % CI

HR

95 % CI

Breast cancer

 3+ prescriptions

176

670

1890.8

1.05

0.79 to 1.40

1.08

0.81 to 1.44

 1–2 prescriptions

60

223

685.3

1

 

1

 

 Any

236

893

2576.0

0.81

0.71 to 0.92

0.80

0.70 to 0.91

 None

1867

10,219

38976.0

1

 

1

 

Colorectal cancer

 3+ prescriptions

148

332

708.2

1.08

0.76 to 1.54

1.06

0.74 to 1.52

 1–2 prescriptions

45

111

247.8

1

 

1

 

 Any

193

443

956.0

0.96

0.82 to 1.12

0.95

0.82 to 1.11

 None

1533

3679

10338.3

1

 

1

 

Lung cancer

 3+ prescriptions

251

324

283.8

1.22

0.95 to 1.56

1.22

0.94 to 1.57

 1–2 prescriptions

87

109

119.3

1

 

1

 

 Any

338

433

403.0

1.09

0.98 to 1.21

1.09

0.98 to 1.22

 None

2418

2919

3069.1

1

 

1

 

Gynaecologic cancer

 3+ prescriptions

78

163

372.6

1.27

0.76 to 2.12

1.24

0.71 to 2.18

 1–2 prescriptions

21

61

145.6

1

 

1

 

 Any

99

224

518.1

0.94

0.75 to 1.17

0.95

0.76 to 1.19

 None

1052

2755

8205.8

1

 

1

 
  1. This sensitivity analysis excludes all supplements prescribed in the year prior to cancer diagnosis
  2. The basic model is adjusted for age and period; the adjusted model is further adjusted for smoking, alcohol, BMI and area-level deprivation