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Table 3 The association of vitamin D and calcium supplementation with survival from selected cancers in women: sensitivity analysis

From: The effect of pre-diagnostic vitamin D supplementation on cancer survival in women: a cohort study within the UK Clinical Practice Research Datalink

  Deaths Cases Person- Basic model Adjusted model
    Years HR 95 % CI HR 95 % CI
Breast cancer
 3+ prescriptions 176 670 1890.8 1.05 0.79 to 1.40 1.08 0.81 to 1.44
 1–2 prescriptions 60 223 685.3 1   1  
 Any 236 893 2576.0 0.81 0.71 to 0.92 0.80 0.70 to 0.91
 None 1867 10,219 38976.0 1   1  
Colorectal cancer
 3+ prescriptions 148 332 708.2 1.08 0.76 to 1.54 1.06 0.74 to 1.52
 1–2 prescriptions 45 111 247.8 1   1  
 Any 193 443 956.0 0.96 0.82 to 1.12 0.95 0.82 to 1.11
 None 1533 3679 10338.3 1   1  
Lung cancer
 3+ prescriptions 251 324 283.8 1.22 0.95 to 1.56 1.22 0.94 to 1.57
 1–2 prescriptions 87 109 119.3 1   1  
 Any 338 433 403.0 1.09 0.98 to 1.21 1.09 0.98 to 1.22
 None 2418 2919 3069.1 1   1  
Gynaecologic cancer
 3+ prescriptions 78 163 372.6 1.27 0.76 to 2.12 1.24 0.71 to 2.18
 1–2 prescriptions 21 61 145.6 1   1  
 Any 99 224 518.1 0.94 0.75 to 1.17 0.95 0.76 to 1.19
 None 1052 2755 8205.8 1   1  
  1. This sensitivity analysis excludes all supplements prescribed in the year prior to cancer diagnosis
  2. The basic model is adjusted for age and period; the adjusted model is further adjusted for smoking, alcohol, BMI and area-level deprivation