Skip to main content

Table 2 Breast cancer risk associated with polymorphic variants in GPX1, GPX4, SEPP1, SEP15 and SOD2 genes

From: Lipid peroxidation and glutathione peroxidase activity relationship in breast cancer depends on functional polymorphism of GPX1

Polymorphism

Cases, n (%)

Controls, n (%)

OR crude (95%CI)

p

OR adjusteda (95 % CI)

p

GPX1 (rs1050450)

Pro/Pro

73 (53.7)

75 (41.0)

1 (ref.)

 

1 (ref.)

 

Leu/Leu

12 (8.8)

23 (12.6)

0.54 (0.25–1.16)

0.112

0.61 (0.28–1.34)

0.215

Pro/Leu + Leu/Leu

63 (46.3)

108 (59.0)

0.60 (0.38–0.94)

0.026

0.61 (0.38–0.97)

0.035

GPX4 (rs713041)

CC

44 (32.4)

65 (35.5)

1 (ref.)

 

1 (ref.)

 

TT

26 (19.1)

28 (15.3)

1.37 (0.71–2.66)

0.345

1.31 (0.65–2.66)

0.445

CT + TT

92 (67.6)

118 (64.5)

1.15 (0.72–1.85)

0.556

1.12 (0.68–1.85)

0.644

SEPP1 (rs3877899)b

Ala/Ala

81 (60.4)

122 (66.7)

1 (ref.)

 

1 (ref.)

 

Thr/Thr

9 (6.7)

6 (3.3)

2.26 (0.77–6.63)

0.136

2.57 (0.86–7.61)

0.087

Ala/Thr + Thr/Thr

53 (39.6)

61 (33.3)

1.31 (0.82–2.08)

0.255

1.38 (0.85–2.23)

0.192

SEP15 (rs5859)

GG

82 (60.3)

103 (56.3)

1 (ref.)

 

1 (ref.)

 

AA

8 (5.9)

14 (7.7)

0.72 (0.28–1.80)

0.479

0.72 (0.27–1.91)

0.512

GA + AA

54 (39.7)

80 (43.7)

0.85 (0.54–1.33)

0.473

0.91 (0.57–1.46)

0.696

SOD2 (rs4880)

Ala/Ala

29 (21.3)

50 (27.3)

1 (ref.)

 

1 (ref.)

 

Val/Val

32 (23.5)

41 (22.4)

1.34 (0.70–2,59)

0.371

1.54 (0.76–3.14)

0.227

Ala/Val + Val/Val

107 (78.7)

133 (72.7)

1.39 (0.82–2.35)

0.221

1.67 (0.95–2.96)

0.076

  1. Significant p values are presented in bold
  2. OR odds ratio, 95 % CI 95 % confidence interval
  3. aOR adjusted for age, BMI, menopausal status and smoking (ever, never)
  4. bgenotype status was unknown in the case of 2 individuals