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Table 2 Breast cancer risk associated with polymorphic variants in GPX1, GPX4, SEPP1, SEP15 and SOD2 genes

From: Lipid peroxidation and glutathione peroxidase activity relationship in breast cancer depends on functional polymorphism of GPX1

Polymorphism Cases, n (%) Controls, n (%) OR crude (95%CI) p OR adjusteda (95 % CI) p
GPX1 (rs1050450)
Pro/Pro 73 (53.7) 75 (41.0) 1 (ref.)   1 (ref.)  
Leu/Leu 12 (8.8) 23 (12.6) 0.54 (0.251.16) 0.112 0.61 (0.28–1.34) 0.215
Pro/Leu + Leu/Leu 63 (46.3) 108 (59.0) 0.60 (0.38–0.94) 0.026 0.61 (0.38–0.97) 0.035
GPX4 (rs713041)
CC 44 (32.4) 65 (35.5) 1 (ref.)   1 (ref.)  
TT 26 (19.1) 28 (15.3) 1.37 (0.71–2.66) 0.345 1.31 (0.65–2.66) 0.445
CT + TT 92 (67.6) 118 (64.5) 1.15 (0.72–1.85) 0.556 1.12 (0.68–1.85) 0.644
SEPP1 (rs3877899)b
Ala/Ala 81 (60.4) 122 (66.7) 1 (ref.)   1 (ref.)  
Thr/Thr 9 (6.7) 6 (3.3) 2.26 (0.77–6.63) 0.136 2.57 (0.86–7.61) 0.087
Ala/Thr + Thr/Thr 53 (39.6) 61 (33.3) 1.31 (0.82–2.08) 0.255 1.38 (0.85–2.23) 0.192
SEP15 (rs5859)
GG 82 (60.3) 103 (56.3) 1 (ref.)   1 (ref.)  
AA 8 (5.9) 14 (7.7) 0.72 (0.28–1.80) 0.479 0.72 (0.27–1.91) 0.512
GA + AA 54 (39.7) 80 (43.7) 0.85 (0.54–1.33) 0.473 0.91 (0.57–1.46) 0.696
SOD2 (rs4880)
Ala/Ala 29 (21.3) 50 (27.3) 1 (ref.)   1 (ref.)  
Val/Val 32 (23.5) 41 (22.4) 1.34 (0.70–2,59) 0.371 1.54 (0.76–3.14) 0.227
Ala/Val + Val/Val 107 (78.7) 133 (72.7) 1.39 (0.82–2.35) 0.221 1.67 (0.95–2.96) 0.076
  1. Significant p values are presented in bold
  2. OR odds ratio, 95 % CI 95 % confidence interval
  3. aOR adjusted for age, BMI, menopausal status and smoking (ever, never)
  4. bgenotype status was unknown in the case of 2 individuals