Lipid peroxidation and glutathione peroxidase activity relationship in breast cancer depends on functional polymorphism of GPX1

Table 1 Characteristics of the study group

	Cases	Controls	p
N	136	183
Age (years)	51.9 ± 6.5 (35–61)	51.4 ± 4.9 (40–60)	0.092^a
BMI (kg/m²)	26.7 ± 4.8 (17.1–43.1)	27.2 ± 4.8 (18.6–48.3)	0.611^a
Smoking status, n (%)
Ever smokers	82 (60)	110 (60)	0.973^b
Never smokers	54 (40)	73 (40)
Current smoking, n (%)
Yes	30 (22)	50 (27)	0.233^b
No	106 (88)	133 (73)
Menopausal status (self-reported), n (%)
Postmenopausal	73 (54)	107 (58)	0.944^b
Premenopausal	51 (37)	76 (42)	0.944^b
Unknown	12 (9)	-
Histological type, n (%)
IDC	109 (80)	na	-
ILC	4 (3)
DCIS	2 (1)
LCIS	1 (1)
Unknown	20 (15)
Tumor stage, n (%)
Tis	3 (2.2)	na	-
T1	60 (44.1)
T2	55 (40.5)
T3	2 (1.5)
T4	3 (2.2)
Tx	3 (2.2)
Unknown	10 (7.3)
Tumor grade, n (%)
G1	8 (5.9)	na	-
G2	44 (32.4)
G3	52 (38.2)
Gx	15 (11.0)
Unknown	17 (12.5)
ER status, n (%)
ER-positive	82 (60)	na	-
ER-negative	32 (24)
Unknown	22 (16)
PR status, n (%)
PR-positive	78 (57.4)	na	-
PR-negative	44 (32.3)
Unknown	14 (10.3)
HER2 status, n (%)
HER2-positive	19 (14.0)	na	-
HER2-negative	94 (69.1)
Unknown	23 (16.9)
Treatment, n (%)
Yes^c	21 (15)	na	-
No	115 (85)

Data for age and BMI expressed as mean ± standard deviation (range)
IDC invasive ductal carcinoma, ILC invasive lobular carcinoma, DCIS ductal carcinoma in situ, LCIS lobular carcinoma in situ, ER estrogen receptors, PR progesterone receptors, HER2 human epidermal growth factor receptors, T tumor stage, G tumor grade, na not applicable
^athe Mann–Whitney test
^bthe Chi-squared test
^cpatients who underwent chemotherapy or breast cancer surgery

ISSN: 1471-2407