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Table 2 Association statistics for combined polymorphisms of CASP8 (− 652 6 N ins/del), FasR-1377 (G > A), FasR-670 (A > G) and FasL-844 (T > C) for cervical cancer cases and controls

From: The combined risks of reduced or increased function variants in cell death pathway genes differentially influence cervical cancer risk and herpes simplex virus type 2 infection among black Africans and the Mixed Ancestry population of South Africa

Black Africans and Mixed Ancestry combined

 Haplotype or Genotype combinations

Cases, n = 442 (frequency)

Controls, n = 278 (frequency)

P-value (global)

  CASP8 + FasR-1377

87 (49)

92 (51)

0.531

  CASP8 + FasR-670

98 (50)

99 (50)

0.63

  CASP8 + FasL-844

97 (50)

98 (50)

0.738

  CASP8 + FasR-1377 + FasR-670

86 (48)

92 (52)

0.813

  CASP8 + FasR-1377 + FasL-844

85 (48)

91 (52)

0.771

  CASP8 + FasR-670 + FasL-844

95 (50)

97 (50)

0.937

  CASP8 + FasR-1377 + FasR-670 + FasL-844

84 (48)

90 (52)

0.978

Among Black Africans

 Combined Polymorphisms

Cases, n = 104 (frequency)

Controls, n = 52 (frequency)

P-value (global)

  CASP8 + FasR-1377

96 (66)

49 (34)

0.138 (global P)

  −652 6 N ins and G

(41)

(28)

0.047 (CPS = 1.99)

  CASP8 + FasR-670

103 (67)

51 (33)

0.028 (global P)

  −652 6 N del and A

(6)

(19)

0.019 (CPS = −2.34)

  CASP8 + FasL-844

103 (67)

51 (33)

0.1 (global P)

  CASP8 + FasR-1377 + FasR-670

96 (67)

48 (33)

0.131 (global P)

  −652 6 N del, G and A

(6)

(19)

0.019 (CPS = −2.35)

  CASP8 + FasR-1377 + FasL-844

95 (66)

48 (34)

0.181 (global P)

  CASP8 + FasR-670 + FasL-844

102 (67)

50 (33)

0.047 (global P)

  −652 6 N del, A and C

(1)

(7)

0.018 (CPS = −2.36)

  CASP8 + FasR-1377 + FasR-670 + FasL-844

95 (67)

47 (33)

0.115 (global P)

  −652 6 N del, G, A and C

(9)

(7)

0.027 (CPS = −2.21)

Among Mixed-Ancestry group

 Haplotypes

Cases, n = 338 (frequency)

Controls, n = 226 (frequency)

P-value (global)

  CASP8 + FasR-1377

289 (58)

208 (42)

0.747

  CASP8 + FasR-670

330 (59)

225 (41)

0.966

  CASP8 + FasL-844

326 (59)

222 (41)

0.909

  CASP8 + FasR-1377 + FasR-670

282 (58)

207 (42)

0.971

  CASP8 + FasR-1377 + FasL-844

280 (58)

204 (42)

0.924

  CASP8 + FasR-670 + FasL-844

320 (59)

221 (41)

0.991

  CASP8 + FasR-1377 + FasR-670 + FasL-844

275 (58)

203 (42)

0.996

  1. P-values and Combined Polymorphism Scores (CPSs) are for test of combined polymorphism association with cervix cancer risk, adjusted for smoking and ethnicity for total cases and controls and smoking only for stratified population groups. CPS = combined polymorphism score. Cases = Women with cancer of the cervix, Controls = Women without cancer of the cervix
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BMC Cancer

ISSN: 1471-2407

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