Table 5 Factors associated with disease-free interval (DFI) in canine invasive mammary carcinomas (n = 150)
Criteria | DFI: Univariate analysis | DFI: Multivariate analysis | ||||
|---|---|---|---|---|---|---|
(log-rank test) N = 150 | (Cox regression model) N = 150 | |||||
HR | 95 % CI | p-value | HR | 95 % CI | p-value | |
Body size | 0.005 | 0.07 | ||||
> 10 kgs | 1.00 | - | 1.00 | |||
≤ 10 kgs | 1.99 | 1.23–3.21 | 1.66 | 0.95–2.90 | ||
Age | 0.007 | 0.02 | ||||
<11 yrs | 1.00 | - | 1.00 | - | ||
≥11 yrs | 1.88 | 1.19–2.98 | 1.91 | 1.13–3.24 | ||
Multifocality | 0.01 | 0.76 | ||||
Unifocal | 1.00 | - | 1.00 | - | ||
Multicentric | 2.56 | 1.22–5.38 | 0.86 | 0.32–2.29 | ||
Histological grade | 0.06 | 0.46 | ||||
Grade I | 1.00 | - | - | 1.00 | - | |
Grade II | 1.90 | 0.89–4.04 | 0.10 | 1.76 | 0.67–4.62 | 0.25 |
Grade III | 2.43 | 1.17–5.06 | 0.02 | 1.83 | 0.69–4.86 | 0.22 |
Lymphovascular invasion | <0.001 | 0.04 | ||||
No LVI | 1.00 | - | 1.00 | - | ||
LVI | 2.86 | 1.81–4.51 | 1.91 | 1.02–3.58 | ||
Surgical margins | 0.005 | 0.15 | ||||
Complete excision | 1.00 | - | 1.00 | - | ||
Incomplete excision | 1.94 | 1.22–3.07 | 1.57 | 0.85–2.88 | ||
Muscle infiltration | 0.005 | 0.99 | ||||
No | 1.00 | - | 1.00 | - | ||
Yes | 2.00 | 1.23–3.28 | 1.00 | 0.54–1.86 | ||
Peritumoral Inflammation | 0.04 | 0.07 | ||||
No | 1.00 | - | 1.00 | - | ||
Yes | 1.57 | 1.00–2.47 | 1.69 | 0.95–2.99 | ||
Central necrosis | 0.03 | 0.04 | ||||
No | 1.00 | - | 1.00 | - | ||
Yes | 0.56 | 0.34–0.93 | 0.52 | 0.28–0.97 | ||
Immunophenotype | 0.02 | 0.18 | ||||
Luminal | 1.00 | - | 1.00 | - | ||
Triple negative | 1.80 | 1.08–3.00 | 1.54 | 0.82–2.86 | ||
CK5/6 | 0.01 | 0.09 | ||||
< 10 % | 1.00 | - | 1.00 | - | ||
≥ 10 % | 0.55 | 0.35–0.87 | 0.61 | 0.34–1.08 | ||
IGF1R | 0.04 | 0.23 | ||||
weak (0–1+) | 1.00 | - | - | 1.00 | - | - |
moderate (2+) | 1.22 | 0.68–2.19 | 0.51 | 1.15 | 0.58–2.28 | 0.70 |
strong (3+) | 2.09 | 1.14–3.83 | 0.02 | 1.74 | 0.86–3.55 | 0.13 |