Table 4 Factors associated with specific survival (SS) in canine invasive mammary carcinomas (n = 150)
Criteria | SS: Univariate analysis | SS: Multivariate analysis | ||||
|---|---|---|---|---|---|---|
(log-rank test) N = 150 | (Cox regression model) N = 150 | |||||
HR | 95 % CI | p-value | HR | 95 % CI | p-value | |
Body size | 0.04 | 0.63 | ||||
> 10 kgs | 1.00 | - | 1.00 | |||
≤ 10 kgs | 1.68 | 1.01–2.78 | 1.16 | 0.64–2.09 | ||
Multifocality | 0.02 | 0.85 | ||||
Unifocal | 1.00 | - | 1.00 | - | ||
Multicentric | 2.36 | 1.12–4.97 | 1.09 | 0.44–2.72 | ||
Lymph node status | 0.001 | |||||
N0 | 1.00 | - | - | - | - | |
N1 | 5.07 | 1.88–13.67 | ||||
Histological grade | 0.01 | 0.44 | ||||
Grade I | 1.00 | - | 1.00 | - | - | |
Grade II | 2.52 | 0.97–6.59 | 0.06 | 2.02 | 0.66–6.23 | 0.22 |
Grade III | 3.74 | 1.47–9.55 | 0.006 | 2.03 | 0.67–6.19 | 0.21 |
Lymphovascular invasion | <0.001 | 0.002 | ||||
No LVI | 1.00 | - | 1.00 | - | ||
LVI | 4.48 | 2.68–7.51 | 2.66 | 1.43–4.94 | ||
Surgical margins | <0.001 | 0.24 | ||||
Complete excision | 1.00 | - | 1.00 | - | ||
Incomplete excision | 2.34 | 1.43–3.83 | 1.46 | 0.77–2.78 | ||
Muscle infiltration | 0.01 | 0.76 | ||||
No | 1.00 | - | 1.00 | - | ||
Yes | 1.88 | 1.14–3.11 | 1.10 | 0.58–2.11 | ||
Peritumoral Inflammation | 0.04 | 0.07 | ||||
No | 1.00 | - | 1.00 | - | ||
Yes | 1.64 | 1.02–2.63 | 1.74 | 0.96–3.15 | ||
Central necrosis | 0.03 | 0.005 | ||||
No | 1.00 | - | 1.00 | - | ||
Yes | 0.57 | 0.34–0.96 | 0.43 | 0.24–0.78 | ||
ER | 0.04 | |||||
≥ 10 % | 1.00 | - | - | - | - | |
< 10 % | 1.91 | 1.02–3.56 | ||||
Ki-67 | 0.01 | 0.29 | ||||
< 20 % | 1.00 | 1.00 | - | |||
≥ 20 % | 2.65 | 1.21–5.80 | 1.70 | 0.64–4.51 | ||
Immunophenotype | 0.004 | 0.06 | ||||
Luminal | 1.00 | - | 1.00 | - | ||
Triple negative | 2.35 | 1.31–4.22 | 1.94 | 0.96–3.88 | ||
IGF1R | 0.001 | 0.03 | ||||
weak (0–1+) | 1.00 | - | - | 1.00 | - | - |
moderate (2+) | 1.68 | 0.82–3.44 | 0.15 | 1.66 | 0.72–3.85 | 0.24 |
strong (3+) | 3.36 | 1.68–6.72 | <0.001 | 2.81 | 1.25–6.31 | 0.01 |