Fig. 1

Immunohistochemical staining of IGF1R expression in normal and neoplastic canine mammary glands. IGF1R (Insulin-like growth factor type 1 receptor) expression was scored according to the intensity of the membrane staining in accordance with the HER-2 scoring system. a Hair follicle positive for IGF1R expression, b Normal mammary gland with a score 2+ for IGF1R, c Invasive ductal mammary carcinoma with a score 0 for IGF1R, d Invasive ductal mammary carcinoma with a score 1+ for IGF1R, (E) Invasive ductal mammary carcinoma with a score 2+ for IGF1R, f Invasive ductal mammary carcinoma with a score 3+ for IGF1R (Immunohistochemical staining, original magnification × 400). Bar = 50 micrometers