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Table 5 Multivariate analyses of prognostic factors in low risk patients (n = 904)

From: Investigation of the feasibility of elective irradiation to neck level Ib using intensity-modulated radiotherapy for patients with nasopharyngeal carcinoma: a retrospective analysis

Variable LR-FFS D-FFS FFS OS
HR (95 % CI) P * HR (95 % CI) P * HR (95 % CI) P * HR (95 % CI) P *
Sex, female vs. male 0.68 (0.34–1.38) .290 0.82 (0.46–1.42) .459 0.82 (0.52–1.29) .384 0.77 (0.37–1.63) .499
Age, ≥50 vs. <50 years 1.27 (0.69–2.32) .445 1.44 (0.87–2.37) .155 1.60 (1.08–2.37) .020 2.44 (1.29–4.60) .006
T classification 1.51 (1.11–2.07) .009 1.32 (1.03–1.70) .029 1.33 (1.08–1.64) .007 1.60 (1.12–2.28) .009
Positive RLNs, (+) vs. (−) 1.70 (0.77–3.73) .185 1.43 (0.76–2.70) .266 1.55 (0.94–2.58) .089 1.17 (0.53–2.57) .694
Positive CLNs, (+) vs. (−) 2.16 (1.20–3.89) .010 2.35 (1.40–3.96) .001 2.01 (1.34–3.04) .001 2.76 (1.44–5.32) .002
Positive CLNs at SCF, (+) vs. (−) 1.16 (0.27–5.04) .846 3.00 (1.24–7.18) .014 2.12 (0.96–4.71) .064 2.69 (0.79–9.12) .113
Chemotherapy, (+) vs. (−) 1.14 (0.38–3.41) .816 1.18 (0.48–2.91) .719 0.89 (0.46–1.71) .717 0.52 (0.20–1.34) .174
Irradiation of level Ib, (+) vs. (−) 1.68 (0.88–3.19) .114 1.43 (0.82–2.49) .207 1.31 (0.83–2.05) .247 0.88 (0.39–1.95) .744
  1. Abbreviations: LR-FFS, locoregional failure-free survival; D-FFS, distant failure-free survival; FFS, failure-free survival; OS, overall survival; HR, hazard ratio; 95 % CI, 95 % confidence interval; RLNs, retropharyngeal lymph nodes; CLNs, cervical lymph nodes; D LN-IIa , greatest dimension of level IIa lymph nodes; LNs, lymph nodes; ES, extra-capsular spread
  2. *P-values were calculated using an adjusted Cox proportional-hazards model