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Table 5 Multivariate analyses of prognostic factors in low risk patients (n = 904)

From: Investigation of the feasibility of elective irradiation to neck level Ib using intensity-modulated radiotherapy for patients with nasopharyngeal carcinoma: a retrospective analysis

Variable

LR-FFS

D-FFS

FFS

OS

HR (95 % CI)

P *

HR (95 % CI)

P *

HR (95 % CI)

P *

HR (95 % CI)

P *

Sex, female vs. male

0.68 (0.34–1.38)

.290

0.82 (0.46–1.42)

.459

0.82 (0.52–1.29)

.384

0.77 (0.37–1.63)

.499

Age, ≥50 vs. <50 years

1.27 (0.69–2.32)

.445

1.44 (0.87–2.37)

.155

1.60 (1.08–2.37)

.020

2.44 (1.29–4.60)

.006

T classification

1.51 (1.11–2.07)

.009

1.32 (1.03–1.70)

.029

1.33 (1.08–1.64)

.007

1.60 (1.12–2.28)

.009

Positive RLNs, (+) vs. (−)

1.70 (0.77–3.73)

.185

1.43 (0.76–2.70)

.266

1.55 (0.94–2.58)

.089

1.17 (0.53–2.57)

.694

Positive CLNs, (+) vs. (−)

2.16 (1.20–3.89)

.010

2.35 (1.40–3.96)

.001

2.01 (1.34–3.04)

.001

2.76 (1.44–5.32)

.002

Positive CLNs at SCF, (+) vs. (−)

1.16 (0.27–5.04)

.846

3.00 (1.24–7.18)

.014

2.12 (0.96–4.71)

.064

2.69 (0.79–9.12)

.113

Chemotherapy, (+) vs. (−)

1.14 (0.38–3.41)

.816

1.18 (0.48–2.91)

.719

0.89 (0.46–1.71)

.717

0.52 (0.20–1.34)

.174

Irradiation of level Ib, (+) vs. (−)

1.68 (0.88–3.19)

.114

1.43 (0.82–2.49)

.207

1.31 (0.83–2.05)

.247

0.88 (0.39–1.95)

.744

  1. Abbreviations: LR-FFS, locoregional failure-free survival; D-FFS, distant failure-free survival; FFS, failure-free survival; OS, overall survival; HR, hazard ratio; 95 % CI, 95 % confidence interval; RLNs, retropharyngeal lymph nodes; CLNs, cervical lymph nodes; D LN-IIa , greatest dimension of level IIa lymph nodes; LNs, lymph nodes; ES, extra-capsular spread
  2. *P-values were calculated using an adjusted Cox proportional-hazards model